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Clinicopathological Features and Prognosis of Mixed-Type T1a Gastric Cancer Based on Lauren's Classification.

Publication ,  Journal Article
Pyo, JH; Ahn, S; Lee, H; Min, B-H; Lee, JH; Shim, SG; Choi, MG; Lee, JH; Sohn, TS; Bae, JM; Kim, K-M; Yeon, S; Jung, S-H; Kim, JJ; Kim, S
Published in: Ann Surg Oncol
December 2016

BACKGROUND: Recent studies have reported that mixed-type (MT) gastric cancer, as per Lauren's classification, exhibits aggressive behavior. However, the behavior of early gastric cancer is unclear. In this study, we addressed the influence of mucosa-confined MT gastric cancer, according to Lauren's classification, on lymph node metastasis (LNM) and long-term outcomes. METHODS: Among patients who underwent gastrectomy for gastric cancer from January 2000 to December 2012, 3170 had mucosa-confined gastric cancer. According to Lauren's classification, 1449 (45.7 %), 1528 (48.2 %), and 193 (6.1 %) patients had intestinal type (IT), diffuse type (DT), and MT cancer, respectively. Moreover, patients with MT cancer were histologically subdivided into IT-predominant MT (3.0 %) and DT-predominant MT (2.5 %) groups. We analyzed and compared the clinicopathological characteristics, incidence of LNM, overall survival, and recurrence-free survival between these groups. RESULTS: Clinicopathological characteristics showed that mucosa-confined MT gastric cancer had larger size, deeper invasion, and more frequent lymphovascular invasion compared with IT or DT cancers. The LNM of MT lesions (4.7 %) was comparable with that of DT lesions (4.8 %), and multivariate logistic regression analysis indicated that Lauren's classification was a significant predictor for LNM (P < 0.001). However, the overall survival and recurrence-free survival of patients with MT lesions did not differ significantly (P = 0.506 and 0.359, respectively). CONCLUSIONS: Thus, among patients with mucosa-confined gastric cancer, those with MT cancer as per Lauren's classification have aggressive clinical features and a risk of LNM. Hence, surgical treatment may be the preferred option in these patients.

Duke Scholars

Published In

Ann Surg Oncol

DOI

EISSN

1534-4681

Publication Date

December 2016

Volume

23

Issue

Suppl 5

Start / End Page

784 / 791

Location

United States

Related Subject Headings

  • Tumor Burden
  • Survival Rate
  • Stomach Neoplasms
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasm Invasiveness
  • Middle Aged
  • Male
  • Lymphatic Irradiation
  • Humans
 

Citation

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Pyo, J. H., Ahn, S., Lee, H., Min, B.-H., Lee, J. H., Shim, S. G., … Kim, S. (2016). Clinicopathological Features and Prognosis of Mixed-Type T1a Gastric Cancer Based on Lauren's Classification. Ann Surg Oncol, 23(Suppl 5), 784–791. https://doi.org/10.1245/s10434-016-5549-9
Pyo, Jeung Hui, Soomin Ahn, Hyuk Lee, Byung-Hoon Min, Jun Haeng Lee, Sang Goon Shim, Min Gew Choi, et al. “Clinicopathological Features and Prognosis of Mixed-Type T1a Gastric Cancer Based on Lauren's Classification.Ann Surg Oncol 23, no. Suppl 5 (December 2016): 784–91. https://doi.org/10.1245/s10434-016-5549-9.
Pyo JH, Ahn S, Lee H, Min B-H, Lee JH, Shim SG, et al. Clinicopathological Features and Prognosis of Mixed-Type T1a Gastric Cancer Based on Lauren's Classification. Ann Surg Oncol. 2016 Dec;23(Suppl 5):784–91.
Pyo, Jeung Hui, et al. “Clinicopathological Features and Prognosis of Mixed-Type T1a Gastric Cancer Based on Lauren's Classification.Ann Surg Oncol, vol. 23, no. Suppl 5, Dec. 2016, pp. 784–91. Pubmed, doi:10.1245/s10434-016-5549-9.
Pyo JH, Ahn S, Lee H, Min B-H, Lee JH, Shim SG, Choi MG, Sohn TS, Bae JM, Kim K-M, Yeon S, Jung S-H, Kim JJ, Kim S. Clinicopathological Features and Prognosis of Mixed-Type T1a Gastric Cancer Based on Lauren's Classification. Ann Surg Oncol. 2016 Dec;23(Suppl 5):784–791.
Journal cover image

Published In

Ann Surg Oncol

DOI

EISSN

1534-4681

Publication Date

December 2016

Volume

23

Issue

Suppl 5

Start / End Page

784 / 791

Location

United States

Related Subject Headings

  • Tumor Burden
  • Survival Rate
  • Stomach Neoplasms
  • Prognosis
  • Oncology & Carcinogenesis
  • Neoplasm Invasiveness
  • Middle Aged
  • Male
  • Lymphatic Irradiation
  • Humans