MRI tools for assessment of microstructure and nephron function of the kidney.

Journal Article (Journal Article;Review)

MRI can provide excellent detail of renal structure and function. Recently, novel MR contrast mechanisms and imaging tools have been developed to evaluate microscopic kidney structures including the tubules and glomeruli. Quantitative MRI can assess local tubular function and is able to determine the concentrating mechanism of the kidney noninvasively in real time. Measuring single nephron function is now a near possibility. In parallel to advancing imaging techniques for kidney microstructure is a need to carefully understand the relationship between the local source of MRI contrast and the underlying physiological change. The development of these imaging markers can impact the accurate diagnosis and treatment of kidney disease. This study reviews the novel tools to examine kidney microstructure and local function and demonstrates the application of these methods in renal pathophysiology.

Full Text

Duke Authors

Cited Authors

  • Xie, L; Bennett, KM; Liu, C; Johnson, GA; Zhang, JL; Lee, VS

Published Date

  • December 1, 2016

Published In

Volume / Issue

  • 311 / 6

Start / End Page

  • F1109 - F1124

PubMed ID

  • 27630064

Pubmed Central ID

  • PMC5210196

Electronic International Standard Serial Number (EISSN)

  • 1522-1466

Digital Object Identifier (DOI)

  • 10.1152/ajprenal.00134.2016


  • eng

Conference Location

  • United States