MRI tools for assessment of microstructure and nephron function of the kidney.
Journal Article (Journal Article;Review)
MRI can provide excellent detail of renal structure and function. Recently, novel MR contrast mechanisms and imaging tools have been developed to evaluate microscopic kidney structures including the tubules and glomeruli. Quantitative MRI can assess local tubular function and is able to determine the concentrating mechanism of the kidney noninvasively in real time. Measuring single nephron function is now a near possibility. In parallel to advancing imaging techniques for kidney microstructure is a need to carefully understand the relationship between the local source of MRI contrast and the underlying physiological change. The development of these imaging markers can impact the accurate diagnosis and treatment of kidney disease. This study reviews the novel tools to examine kidney microstructure and local function and demonstrates the application of these methods in renal pathophysiology.
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Duke Authors
Cited Authors
- Xie, L; Bennett, KM; Liu, C; Johnson, GA; Zhang, JL; Lee, VS
Published Date
- December 1, 2016
Published In
Volume / Issue
- 311 / 6
Start / End Page
- F1109 - F1124
PubMed ID
- 27630064
Pubmed Central ID
- PMC5210196
Electronic International Standard Serial Number (EISSN)
- 1522-1466
Digital Object Identifier (DOI)
- 10.1152/ajprenal.00134.2016
Language
- eng
Conference Location
- United States