Osteopontin has a protective role in prostate tumor development in mice.

Journal Article (Journal Article)

Osteopontin (OPN) is a protein, generally considered to play a pro-tumorigenic role, whereas several reports have demonstrated the anti-tumorigenic function of OPN during tumor development. These opposing anti- and pro-tumorigenic functions are not fully understood. Here, we report that host-derived OPN plays an anti-tumorigenic role in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model and a TRAMP tumor transplant model. Tumor suppression mediated by OPN in Rag2-/- mice suggests that OPN is dispensable in the adaptive immune response. We found that host-derived OPN enhanced infiltration of natural killer (NK) cells into TRAMP tumors. The requirement of OPN in NK cell migration towards TRAMP cells was confirmed by an ex vivo cell migration assay. In contrast to TRAMP cells, in vivo B16 tumor development was not inhibited by OPN, and B16 tumors did not show OPN-mediated cell recruitment. It is possible that low levels of chemokine expression by B16 cells do not allow OPN to enhance immune cell recruitment. In addition to demonstrating the anti-tumorigenic role of OPN in TRAMP tumor development, this study also suggests that the contribution of OPN to tumor development depends on the type of tumor as well as the source and isoform of OPN.

Full Text

Duke Authors

Cited Authors

  • Danzaki, K; Kanayama, M; Alcazar, O; Shinohara, ML

Published Date

  • November 2016

Published In

Volume / Issue

  • 46 / 11

Start / End Page

  • 2669 - 2678

PubMed ID

  • 27601131

Electronic International Standard Serial Number (EISSN)

  • 1521-4141

Digital Object Identifier (DOI)

  • 10.1002/eji.201646391


  • eng

Conference Location

  • Germany