Carbon extension in peptidylnucleoside biosynthesis by radical SAM enzymes.
Publication
, Journal Article
Lilla, EA; Yokoyama, K
Published in: Nat Chem Biol
November 2016
Nikkomycins and polyoxins are antifungal peptidylnucleoside antibiotics active against human and plant pathogens. Here we report that during peptidylnucleoside biosynthesis in Streptomyces cacaoi and S. tendae, the C5' extension of the nucleoside essential for downstream structural diversification is catalyzed by a conserved radical S-adenosyl-L-methionine (SAM) enzyme, PolH or NikJ. This is distinct from the nucleophilic mechanism reported for antibacterial nucleosides and represents a new mechanism of nucleoside natural product biosynthesis.
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Published In
Nat Chem Biol
DOI
EISSN
1552-4469
Publication Date
November 2016
Volume
12
Issue
11
Start / End Page
905 / 907
Location
United States
Related Subject Headings
- Streptomyces
- S-Adenosylmethionine
- Protein Methyltransferases
- Peptides
- Nucleosides
- Molecular Conformation
- Free Radicals
- Carbon
- Biochemistry & Molecular Biology
- 3404 Medicinal and biomolecular chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Lilla, E. A., & Yokoyama, K. (2016). Carbon extension in peptidylnucleoside biosynthesis by radical SAM enzymes. Nat Chem Biol, 12(11), 905–907. https://doi.org/10.1038/nchembio.2187
Lilla, Edward A., and Kenichi Yokoyama. “Carbon extension in peptidylnucleoside biosynthesis by radical SAM enzymes.” Nat Chem Biol 12, no. 11 (November 2016): 905–7. https://doi.org/10.1038/nchembio.2187.
Lilla EA, Yokoyama K. Carbon extension in peptidylnucleoside biosynthesis by radical SAM enzymes. Nat Chem Biol. 2016 Nov;12(11):905–7.
Lilla, Edward A., and Kenichi Yokoyama. “Carbon extension in peptidylnucleoside biosynthesis by radical SAM enzymes.” Nat Chem Biol, vol. 12, no. 11, Nov. 2016, pp. 905–07. Pubmed, doi:10.1038/nchembio.2187.
Lilla EA, Yokoyama K. Carbon extension in peptidylnucleoside biosynthesis by radical SAM enzymes. Nat Chem Biol. 2016 Nov;12(11):905–907.
Published In
Nat Chem Biol
DOI
EISSN
1552-4469
Publication Date
November 2016
Volume
12
Issue
11
Start / End Page
905 / 907
Location
United States
Related Subject Headings
- Streptomyces
- S-Adenosylmethionine
- Protein Methyltransferases
- Peptides
- Nucleosides
- Molecular Conformation
- Free Radicals
- Carbon
- Biochemistry & Molecular Biology
- 3404 Medicinal and biomolecular chemistry