Immune responses to transplants

Book Section

© 2016 by John Wiley & Sons, Ltd. All rights reserved. Organ transplantation is the accepted and indeed the preferred treatment for most forms of end-stage organ failure. While the function of the immune system may be to protect against infection or "danger", the immune system, if not suppressed, also efficiently recognizes an organ transplant from a genetically disparate individual. This initiates an immune response, or an alloresponse, against the transplant. The alloimmune response involves adaptive and innate immune systems; T and B cells are the principle mediators of cellular and antibody-mediated rejection. Distinct immunologic and histologic differences exist between acute cellular, antibody mediated, and chronic rejection. Tolerance strategies include immunoregulation, costimulation blockade, and mixed chimerism; mechanisms of tolerance induction may differ from those that are needed to sustain it. Memory T cells are a significant barrier to tolerance induction. Identification of biomarkers for rejection and/or tolerance could initiate individualized immune modulation regimens.

Full Text

Duke Authors

Cited Authors

  • Lo, DJ; Kirk, AD

Published Date

  • September 12, 2015

Book Title

  • Transplant Immunology

Start / End Page

  • 142 - 163

International Standard Book Number 13 (ISBN-13)

  • 9781119072997

Digital Object Identifier (DOI)

  • 10.1002/9781119072997.ch8

Citation Source

  • Scopus