Clinical perspectives on reperfusion injury in acute myocardial infarction.

Journal Article (Journal Article;Review)

Prompt reperfusion therapy in acute myocardial infarction enhances clinical outcome. However, reperfusion itself may contribute to myocardial cell death. The current review outlines the multifocal mechanisms of reperfusion injury and focuses on understanding the potential role of each element and its contribution to the injury pattern inflicted upon the myocardium. We evaluate the spectrum of contemporary therapies that have been tested in an attempt to reduce myocardial injury. Finally, we explore promising innovative strategies targeting novel reperfusion injury pathways to protect ischemic myocardium during reperfusion.

Full Text

Duke Authors

Cited Authors

  • Bainey, KR; Armstrong, PW

Published Date

  • May 2014

Published In

Volume / Issue

  • 167 / 5

Start / End Page

  • 637 - 645

PubMed ID

  • 24766972

Electronic International Standard Serial Number (EISSN)

  • 1097-6744

Digital Object Identifier (DOI)

  • 10.1016/j.ahj.2014.01.015


  • eng

Conference Location

  • United States