Adipokines and cytokines in non-alcoholic fatty liver disease.


Journal Article

BACKGROUND:Several adipocytokines have been implicated in the pathogenesis non-alcoholic fatty liver disease (NAFLD). AIM:To assess adipocytokines in NAFLD patients and controls. METHODS:A total of 95 patients (26 non-alcoholic steatohepatitis (NASH), 19 simple steatosis (SS), 38 obese controls and 12 non-obese controls) were included. Fasting serum insulin, glucose, visfatin, resistin, adiponectin, tumour necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8) and IL-6 were determined. Univariate and multivariate analyses were used to compare groups and determine associations. RESULTS:Serum TNF-alpha and IL-8 were higher in NAFLD patients when compared with both obese and non-obese controls. Analysis involving all patients revealed a significant correlation between serum TNF-alpha and IL-8 (P < 6.319e-08), and between IL-6 and IL-8 (P < 5.271e-15). Homeostatic model assessment scores negatively correlated with adiponectin in NAFLD (P < 0.0032). Serum visfatin was higher in all three obese groups than in non-obese controls (P < 0.02, P < 0.002 and P < 0.008). Visfatin in NASH patients was lower than SS and obese controls. Although TNF-alpha was associated with NAFLD (P < 0.02), it was interdependent on visfatin. In comparison to SS, four factors were independently associated with NASH: age, alanine aminotransferase, IL-8 and adiponectin (P < 0.05). Multivariate analysis indicated that TNF-alpha was the only independent predictor of fibrosis in NASH (P < 0.0004). CONCLUSION:These findings support a complex interaction between adipocytokines and the pathogenesis of NAFLD.

Full Text

Cited Authors

  • Jarrar, MH; Baranova, A; Collantes, R; Ranard, B; Stepanova, M; Bennett, C; Fang, Y; Elariny, H; Goodman, Z; Chandhoke, V; Younossi, ZM

Published Date

  • March 2008

Published In

Volume / Issue

  • 27 / 5

Start / End Page

  • 412 - 421

PubMed ID

  • 18081738

Pubmed Central ID

  • 18081738

Electronic International Standard Serial Number (EISSN)

  • 1365-2036

International Standard Serial Number (ISSN)

  • 0269-2813

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2036.2007.03586.x


  • eng