The renin-angiotensin system and prevention of age-related functional decline: where are we now?

Journal Article (Journal Article;Review)

Declining physical function is a major health problem for older adults as it is associated with multiple comorbidities and mortality. Exercise has been shown to improve physical function, though response to exercise is variable. Conversely, drugs targeting the renin-angiotensin system (RAS) pathway, including angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARBs), are also reported to improve physical function. In the past decade, significant strides have been made to understand the complexity and specificity of the RAS system as it pertains to physical function in older adults. Prior findings have also determined that interactions between antihypertensive medications and exercise may influence physical function above and beyond either factor alone. We review the latest research on RAS, exercise, and physical function for older adults. We also outline future research aims in this area, including genetic influences and clinical phenotyping, for the purpose of maintaining or improving physical function through tailored treatments.

Full Text

Duke Authors

Cited Authors

  • Simon, CB; Lee-McMullen, B; Phelan, D; Gilkes, J; Carter, CS; Buford, TW

Published Date

  • February 2015

Published In

Volume / Issue

  • 37 / 1

Start / End Page

  • 9753 -

PubMed ID

  • 25663422

Pubmed Central ID

  • PMC4320995

Electronic International Standard Serial Number (EISSN)

  • 1574-4647

Digital Object Identifier (DOI)

  • 10.1007/s11357-015-9753-5


  • eng

Conference Location

  • Netherlands