Asymmetric division: An antitumor player?


Journal Article

miR-34a-mediated asymmetric cell division reins in excessive stem cell expansion during tissue regeneration in the intestine and colon. Loss of miR-34a switches asymmetric division to symmetric division and enhances stem cell proliferation. Asymmetric division also occurs in the early stages of colon cancer stem cells. Mechanistically, miR-34a, Numb, and Notch form a feed-forward loop that specifies cell fate when stem cells divide.

Full Text

Duke Authors

Cited Authors

  • Wang, L; Bu, P; Shen, X

Published Date

  • July 2016

Published In

Volume / Issue

  • 3 / 4

Start / End Page

  • e1164279 -

PubMed ID

  • 27652318

Pubmed Central ID

  • 27652318

Electronic International Standard Serial Number (EISSN)

  • 2372-3556

International Standard Serial Number (ISSN)

  • 2372-3556

Digital Object Identifier (DOI)

  • 10.1080/23723556.2016.1164279


  • eng