CD34 and α smooth muscle actin distinguish verrucous hyperplasia from verrucous carcinoma.


Journal Article

OBJECTIVE: This study evaluated the use of stromal biomarkers CD34 and α smooth muscle actin (α-SMA) to distinguish verrucous carcinoma (VC) from verrucous hyperplasia (VH). STUDY DESIGN: Thirteen VH, 15 VC, 20 squamous cell carcinoma (SCC), and 16 of uninvolved adjacent stroma specimens were analyzed for α-SMA and CD34 expression by immunohistochemistry. RESULTS: Stromal α-SMA positivity was observed in 100% (20 of 20) of the SCC and in 93% (14 of 15) of the VC, whereas none of the VH (0 of 13) or adjacent uninvolved stroma (0 of 16) demonstrated α-SMA reactivity. Stromal CD34 positivity was observed in 100% (13 of 13) of VH and adjacent stroma (16 of 16), while 20% (3 of 15) of VC and 11% (2 of 18) of SCC stroma expressed CD34. The SCC and VC groups differed significantly from the VH and uninvolved stroma groups for both α-SMA and CD34 expression (P < .0001). CONCLUSIONS: Stromal CD34 and α-SMA protein expression patterns may aid in distinguishing between VC and VH in challenging cases.

Full Text

Cited Authors

  • Paral, KM; Taxy, JB; Lingen, MW

Published Date

  • April 2014

Published In

Volume / Issue

  • 117 / 4

Start / End Page

  • 477 - 482

PubMed ID

  • 24560559

Pubmed Central ID

  • 24560559

Electronic International Standard Serial Number (EISSN)

  • 2212-4411

International Standard Serial Number (ISSN)

  • 2212-4403

Digital Object Identifier (DOI)

  • 10.1016/j.oooo.2013.12.401


  • eng