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Serious infections among unselected patients with ST-elevation myocardial infarction treated with contemporary primary percutaneous coronary intervention.

Publication ,  Journal Article
Piccaro de Oliveira, P; Gonzales, V; Lopes, RD; Schmidt, MM; Garofallo, S; Santos, RPD; Carrion, L; Gottschall, C; Quadros, AS
Published in: Am Heart J
November 2016

BACKGROUND: Contemporary studies assessing the frequency, characteristics, and outcomes of serious infections (SIs) in patients presenting a ST-elevation myocardial infarction are scarce. METHODS: Prospective cohort of consecutive patients undergoing primary percutaneous coronary intervention (pPCI). Serious infection was defined as the presence of infection that prolonged hospitalization. Community-acquired infection (CAI) was defined by SI diagnosed in the first 72 hours of hospitalization, whereas hospital-acquired infections (HAI) were those diagnosed after 72 hours of hospital admission. RESULTS: From December 2009 to November 2012, 1,486 patients were included in the analysis. Serious infection was present in 58 (3.9%) individuals; 30 (2%) patients had CAI and 28 (1.9%) patients had HAI. Respiratory tract infection was responsible for 82% of the SI. Patients with SI were older, had more comorbidities, and had worse angiographic results of the pPCI procedure when compared with those without SIs. After multivariable adjustment, SI was associated with an approximately 10-fold risk of 30-day death. Patients with CAI had more often a history of smoking, Killip III/IV on hospital admission, worse pPCI, and angiographic results than did patients with HAI. However, no differences were seen in 30-day major cardiovascular outcomes between patients with CAI and HAI. CONCLUSION: In a contemporary cohort of unselected ST-elevation myocardial infarction patients representative of the daily practice, SI was uncommon but associated with worse pPCI results and high risk of mortality. The occurrences of CAI or HAI were similar, but CAI patients presented distinctly worse angiographic outcomes than did patients with HAI.

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

November 2016

Volume

181

Start / End Page

52 / 59

Location

United States

Related Subject Headings

  • Urinary Tract Infections
  • Treatment Outcome
  • Streptococcal Infections
  • Staphylococcal Infections
  • Smoking
  • Sepsis
  • ST Elevation Myocardial Infarction
  • Respiratory Tract Infections
  • Pseudomonas Infections
  • Prospective Studies
 

Citation

APA
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ICMJE
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Piccaro de Oliveira, P., Gonzales, V., Lopes, R. D., Schmidt, M. M., Garofallo, S., Santos, R. P. D., … Quadros, A. S. (2016). Serious infections among unselected patients with ST-elevation myocardial infarction treated with contemporary primary percutaneous coronary intervention. Am Heart J, 181, 52–59. https://doi.org/10.1016/j.ahj.2016.08.005
Piccaro de Oliveira, Pedro, Vinicius Gonzales, Renato D. Lopes, Marcia Moura Schmidt, Silvia Garofallo, Rodrigo Pires Dos Santos, Luciana Carrion, Carlos Gottschall, and Alexandre S. Quadros. “Serious infections among unselected patients with ST-elevation myocardial infarction treated with contemporary primary percutaneous coronary intervention.Am Heart J 181 (November 2016): 52–59. https://doi.org/10.1016/j.ahj.2016.08.005.
Piccaro de Oliveira P, Gonzales V, Lopes RD, Schmidt MM, Garofallo S, Santos RPD, et al. Serious infections among unselected patients with ST-elevation myocardial infarction treated with contemporary primary percutaneous coronary intervention. Am Heart J. 2016 Nov;181:52–9.
Piccaro de Oliveira, Pedro, et al. “Serious infections among unselected patients with ST-elevation myocardial infarction treated with contemporary primary percutaneous coronary intervention.Am Heart J, vol. 181, Nov. 2016, pp. 52–59. Pubmed, doi:10.1016/j.ahj.2016.08.005.
Piccaro de Oliveira P, Gonzales V, Lopes RD, Schmidt MM, Garofallo S, Santos RPD, Carrion L, Gottschall C, Quadros AS. Serious infections among unselected patients with ST-elevation myocardial infarction treated with contemporary primary percutaneous coronary intervention. Am Heart J. 2016 Nov;181:52–59.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

November 2016

Volume

181

Start / End Page

52 / 59

Location

United States

Related Subject Headings

  • Urinary Tract Infections
  • Treatment Outcome
  • Streptococcal Infections
  • Staphylococcal Infections
  • Smoking
  • Sepsis
  • ST Elevation Myocardial Infarction
  • Respiratory Tract Infections
  • Pseudomonas Infections
  • Prospective Studies