Unfolded protein response in brain ischemia: A timely update.

Published

Journal Article (Review)

Folding and processing newly synthesized proteins are vital functions of the endoplasmic reticulum that are sensitive to a variety of stress conditions. The unfolded protein response is activated to restore endoplasmic reticulum function impaired by stress. While we know that brain ischemia impairs endoplasmic reticulum function, the role of unfolded protein response activation in post-ischemic recovery of neurologic function is only beginning to emerge. Here, we summarize what is known about endoplasmic reticulum stress and unfolded protein response in brain ischemia and discuss recent findings from myocardial ischemia studies that could help to advance research on endoplasmic reticulum stress and unfolded protein response in brain ischemia.

Full Text

Duke Authors

Cited Authors

  • Yang, W; Paschen, W

Published Date

  • December 2016

Published In

Volume / Issue

  • 36 / 12

Start / End Page

  • 2044 - 2050

PubMed ID

  • 27733676

Pubmed Central ID

  • 27733676

Electronic International Standard Serial Number (EISSN)

  • 1559-7016

Digital Object Identifier (DOI)

  • 10.1177/0271678X16674488

Language

  • eng

Conference Location

  • United States