Unfolded protein response in brain ischemia: A timely update.
Folding and processing newly synthesized proteins are vital functions of the endoplasmic reticulum that are sensitive to a variety of stress conditions. The unfolded protein response is activated to restore endoplasmic reticulum function impaired by stress. While we know that brain ischemia impairs endoplasmic reticulum function, the role of unfolded protein response activation in post-ischemic recovery of neurologic function is only beginning to emerge. Here, we summarize what is known about endoplasmic reticulum stress and unfolded protein response in brain ischemia and discuss recent findings from myocardial ischemia studies that could help to advance research on endoplasmic reticulum stress and unfolded protein response in brain ischemia.
Duke Scholars
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Related Subject Headings
- Unfolded Protein Response
- Recovery of Function
- Neurology & Neurosurgery
- Humans
- Endoplasmic Reticulum Stress
- Brain Ischemia
- 3209 Neurosciences
- 3202 Clinical sciences
- 1109 Neurosciences
- 1103 Clinical Sciences
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Unfolded Protein Response
- Recovery of Function
- Neurology & Neurosurgery
- Humans
- Endoplasmic Reticulum Stress
- Brain Ischemia
- 3209 Neurosciences
- 3202 Clinical sciences
- 1109 Neurosciences
- 1103 Clinical Sciences