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A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer.

Publication ,  Journal Article
Yuan, H; Liu, H; Liu, Z; Owzar, K; Han, Y; Su, L; Wei, Y; Hung, RJ; McLaughlin, J; Brhane, Y; Brennan, P; Bickeboeller, H; Rosenberger, A ...
Published in: Sci Rep
October 7, 2016

Lung cancer etiology is multifactorial, and growing evidence has indicated that long non-coding RNAs (lncRNAs) are important players in lung carcinogenesis. We performed a large-scale meta-analysis of 690,564 SNPs in 15,531 autosomal lncRNAs by using datasets from six previously published genome-wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium in populations of European ancestry. Previously unreported significant SNPs (P value < 1 × 10-7) were further validated in two additional independent lung cancer GWAS datasets from Harvard University and deCODE. In the final meta-analysis of all eight GWAS datasets with 17,153 cases and 239,337 controls, a novel risk SNP rs114020893 in the lncRNA NEXN-AS1 region at 1p31.1 remained statistically significant (odds ratio = 1.17; 95% confidence interval = 1.11-1.24; P = 8.31 × 10-9). In further in silico analysis, rs114020893 was predicted to change the secondary structure of the lncRNA. Our finding indicates that SNP rs114020893 of NEXN-AS1 at 1p31.1 may contribute to lung cancer susceptibility.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

October 7, 2016

Volume

6

Start / End Page

34234

Location

England

Related Subject Headings

  • Risk Factors
  • RNA, Long Noncoding
  • Polymorphism, Single Nucleotide
  • Nucleic Acid Conformation
  • Male
  • Lung Neoplasms
  • Humans
  • Genome-Wide Association Study
  • Female
 

Citation

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Yuan, H., Liu, H., Liu, Z., Owzar, K., Han, Y., Su, L., … Wei, Q. (2016). A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer. Sci Rep, 6, 34234. https://doi.org/10.1038/srep34234
Yuan, Hua, Hongliang Liu, Zhensheng Liu, Kouros Owzar, Younghun Han, Li Su, Yongyue Wei, et al. “A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer.Sci Rep 6 (October 7, 2016): 34234. https://doi.org/10.1038/srep34234.
Yuan H, Liu H, Liu Z, Owzar K, Han Y, Su L, et al. A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer. Sci Rep. 2016 Oct 7;6:34234.
Yuan, Hua, et al. “A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer.Sci Rep, vol. 6, Oct. 2016, p. 34234. Pubmed, doi:10.1038/srep34234.
Yuan H, Liu H, Liu Z, Owzar K, Han Y, Su L, Wei Y, Hung RJ, McLaughlin J, Brhane Y, Brennan P, Bickeboeller H, Rosenberger A, Houlston RS, Caporaso N, Landi MT, Heinrich J, Risch A, Christiani DC, Gümüş ZH, Klein RJ, Amos CI, Wei Q. A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer. Sci Rep. 2016 Oct 7;6:34234.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

October 7, 2016

Volume

6

Start / End Page

34234

Location

England

Related Subject Headings

  • Risk Factors
  • RNA, Long Noncoding
  • Polymorphism, Single Nucleotide
  • Nucleic Acid Conformation
  • Male
  • Lung Neoplasms
  • Humans
  • Genome-Wide Association Study
  • Female