Racial, Socioeconomic, and Gender Disparities in the Presentation, Treatment, and Outcomes of Adult Chiari I Malformations.
Journal Article (Journal Article)
OBJECTIVE: To examine the influence of race, gender, and socioeconomic factors on presentations and outcomes of adult Chiari I malformations. METHODS: The charts of 638 adult patients with Chiari I malformations were reviewed, and 287 patients were included in the study. Race, gender, insurance status, symptoms, depth of cerebellar tonsillar herniation, and presence of syringomyelia were examined as covariates in multivariate logistic regression models to identify independent predictors of presentation and outcome. RESULTS: Patients with public insurance had a longer stay in the hospital (P = 0.01). A higher proportion of male patients presented with upper extremity weakness (P = 0.01), lower extremity weakness (P = 0.040), and cranial nerve findings (P = 0.02). Men had shorter onset to diagnosis times (P = 0.02), worse tonsillar herniation (P = 0.03), and more severe symptoms (P = 0.05). White patients more frequently presented with back pain (P = 0.03), and African American patients more frequently presented with lower extremity weakness (P = 0.01). African Americans had worse tonsillar herniation (P < 0.01) and were more likely to present with syringomyelia (P = 0.01). Multivariate regression analysis revealed that back pain (P < 0.01), upper extremity weakness (P ≤ 0.01), upper extremity paresthesias (P < 0.01), and upper with lower extremity paresthesias (P = 0.04) were significant predictors of syringomyelia. The only independent predictor of outcome was size of tonsillar herniation (P = 0.03). CONCLUSIONS: Significant differences in presentation of Chiari I malformation resulting from gender, race, and insurance status were quantified for the first time.
Full Text
Duke Authors
Cited Authors
- Krucoff, MO; Cook, S; Adogwa, O; Moreno, J; Yang, S; Xie, J; Firempong, AO; Lad, N; Bagley, CA
Published Date
- January 2017
Published In
Volume / Issue
- 97 /
Start / End Page
- 431 - 437
PubMed ID
- 27751919
Electronic International Standard Serial Number (EISSN)
- 1878-8769
Digital Object Identifier (DOI)
- 10.1016/j.wneu.2016.10.026
Language
- eng
Conference Location
- United States