Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni.
Journal Article (Journal Article)
Schistosomiasis is a major cause of fibrosis and portal hypertension. The reason 4-10% of infected subjects develops hepatosplenic schistosomiasis remains unclear. Chronically infected male CBA/J mice reproduce the dichotomic forms of human schistosomiasis. Most mice (80%) develop moderate splenomegaly syndrome (similar to hepatointestinal disease in humans) and 20% present severe hypersplenomegaly syndrome (analogous to human hepatosplenic disease). We demonstrated that the profibrogenic molecule osteopontin discriminates between mice with severe and mild disease and could be a novel morbidity biomarker in murine and human schistosomiasis. Failure to downregulate osteopontin during the chronic phase may explain why hepatosplenic subjects develop severe fibrosis.
Full Text
Duke Authors
Cited Authors
- Pereira, TA; Syn, W-K; Pereira, FEL; Lambertucci, JR; Secor, WE; Diehl, AM
Published Date
- December 2016
Published In
Volume / Issue
- 46 / 13-14
Start / End Page
- 829 - 832
PubMed ID
- 27729270
Pubmed Central ID
- PMC5584370
Electronic International Standard Serial Number (EISSN)
- 1879-0135
Digital Object Identifier (DOI)
- 10.1016/j.ijpara.2016.08.004
Language
- eng
Conference Location
- England