Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni.

Journal Article

Schistosomiasis is a major cause of fibrosis and portal hypertension. The reason 4-10% of infected subjects develops hepatosplenic schistosomiasis remains unclear. Chronically infected male CBA/J mice reproduce the dichotomic forms of human schistosomiasis. Most mice (80%) develop moderate splenomegaly syndrome (similar to hepatointestinal disease in humans) and 20% present severe hypersplenomegaly syndrome (analogous to human hepatosplenic disease). We demonstrated that the profibrogenic molecule osteopontin discriminates between mice with severe and mild disease and could be a novel morbidity biomarker in murine and human schistosomiasis. Failure to downregulate osteopontin during the chronic phase may explain why hepatosplenic subjects develop severe fibrosis.

Full Text

Duke Authors

Cited Authors

  • Pereira, TA; Syn, W-K; Pereira, FEL; Lambertucci, JR; Secor, WE; Diehl, AM

Published Date

  • December 2016

Published In

Volume / Issue

  • 46 / 13-14

Start / End Page

  • 829 - 832

PubMed ID

  • 27729270

Electronic International Standard Serial Number (EISSN)

  • 1879-0135

International Standard Serial Number (ISSN)

  • 0020-7519

Digital Object Identifier (DOI)

  • 10.1016/j.ijpara.2016.08.004

Language

  • eng