IKK/NF-κB signaling contributes to glioblastoma stem cell maintenance.

Published

Journal Article

Glioblastoma multiforme (GBM) carries a poor prognosis and continues to lack effective treatments. Glioblastoma stem cells (GSCs) drive tumor formation, invasion, and drug resistance and, as such, are the focus of studies to identify new therapies for disease control. Here, we identify the involvement of IKK and NF-κB signaling in the maintenance of GSCs. Inhibition of this pathway impairs self-renewal as analyzed in tumorsphere formation and GBM expansion as analyzed in brain slice culture. Interestingly, both the canonical and non-canonical branches of the NF-κB pathway are shown to contribute to this phenotype. One source of NF-κB activation in GBM involves the TGF-β/TAK1 signaling axis. Together, our results demonstrate a role for the NF-κB pathway in GSCs and provide a mechanistic basis for its potential as a therapeutic target in glioblastoma.

Full Text

Cited Authors

  • Rinkenbaugh, AL; Cogswell, PC; Calamini, B; Dunn, DE; Persson, AI; Weiss, WA; Lo, DC; Baldwin, AS

Published Date

  • October 2016

Published In

Volume / Issue

  • 7 / 43

Start / End Page

  • 69173 - 69187

PubMed ID

  • 27732951

Pubmed Central ID

  • 27732951

Electronic International Standard Serial Number (EISSN)

  • 1949-2553

International Standard Serial Number (ISSN)

  • 1949-2553

Digital Object Identifier (DOI)

  • 10.18632/oncotarget.12507

Language

  • eng