An oxytocin receptor polymorphism predicts amygdala reactivity and antisocial behavior in men.

Journal Article (Journal Article)

Variability in oxytocin (OXT) signaling is associated with individual differences in sex-specific social behavior across species. The effects of OXT signaling on social behavior are, in part, mediated through its modulation of amygdala function. Here, we use imaging genetics to examine sex-specific effects of three single-nucleotide polymorphisms in the human oxytocin receptor gene (OXTR; rs1042778, rs53576 and rs2254298) on threat-related amygdala reactivity and social behavior in 406 Caucasians. Analyses revealed that among men but not women, OXTR rs1042778 TT genotype was associated with increased right amygdala reactivity to angry facial expressions, which was uniquely related to higher levels of antisocial behavior among men. Moderated meditation analysis suggested a trending indirect effect of OXTR rs1042778 TT genotype on higher antisocial behavior via increased right amygdala reactivity to angry facial expressions in men. Our results provide evidence linking genetic variation in OXT signaling to individual differences in amygdala function. The results further suggest that these pathways may be uniquely important in shaping antisocial behavior in men.

Full Text

Duke Authors

Cited Authors

  • Waller, R; Corral-Frías, NS; Vannucci, B; Bogdan, R; Knodt, AR; Hariri, AR; Hyde, LW

Published Date

  • August 2016

Published In

Volume / Issue

  • 11 / 8

Start / End Page

  • 1218 - 1226

PubMed ID

  • 27036876

Pubmed Central ID

  • PMC4967804

Electronic International Standard Serial Number (EISSN)

  • 1749-5024

International Standard Serial Number (ISSN)

  • 1749-5016

Digital Object Identifier (DOI)

  • 10.1093/scan/nsw042


  • eng