Prevention and management of bronchopulmonary dysplasia: Lessons learned from the neonatal research network.

Journal Article (Journal Article;Review)

Despite remarkable improvements in survival of extremely premature infants, the burden of BPD among survivors remains a frustrating problem for parents and caregivers. Advances, such as antenatal steroids and surfactant replacement, which have dramatically improved survival, have not reduced BPD among survivors. Other advances that have significantly improved the combined outcome of death or BPD, such as vitamin A and avoidance of mechanical ventilation, have had smaller magnitude effects on the outcome of BPD alone. Postnatal steroids have a clear beneficial effect on BPD, but the optimal preparation, dose, and timing for maximizing benefit and minimizing harm have yet to be determined. This persistent burden of BPD among the most immature survivors remains a challenge for the NRN and other researchers in neonatal medicine.

Full Text

Duke Authors

Cited Authors

  • Kennedy, KA; Cotten, CM; Watterberg, KL; Carlo, WA

Published Date

  • October 2016

Published In

Volume / Issue

  • 40 / 6

Start / End Page

  • 348 - 355

PubMed ID

  • 27742002

Pubmed Central ID

  • PMC5279709

Electronic International Standard Serial Number (EISSN)

  • 1558-075X

Digital Object Identifier (DOI)

  • 10.1053/j.semperi.2016.05.010


  • eng

Conference Location

  • United States