Developmental biology of hepatic phenylalanine hydroxylase activity in foetal and neonatal rats synchronized as to conception


Journal Article

A biphasic pattern of development of phenylalanine hydroxylase activity is found in foetal and neonatal rats synchronized as to conception. The first burst of activity is at 22 days and 12 h. The second burst activty occurs between 2 and 3 weeks of age. Progesterone decreases the maximal level of enzyme activity achieved during the initial burst. However, the fundamental biphasic pattern seems to be independent of birth, progesterone or maternal milk. Hypophysectomy, thyroidectomy and adrenalectomy do not result in a significant change of enzymatic activity in the 26-day-old rat. The activity of phenylalanine hydroxylase is maintained at a constant steady state during a 24-h cycle in the 6-week-old rat. © 1972.

Full Text

Duke Authors

Cited Authors

  • Tourian, A; Treiman, DM; Carr, JS

Published Date

  • October 25, 1972

Published In

Volume / Issue

  • 279 / 3

Start / End Page

  • 484 - 490

PubMed ID

  • 4673311

Pubmed Central ID

  • 4673311

International Standard Serial Number (ISSN)

  • 0304-4165

Digital Object Identifier (DOI)

  • 10.1016/0304-4165(72)90170-5

Citation Source

  • Scopus