Huntington's-chorea fibroblasts. Cellular protein glycosylation.

Journal Article (Journal Article)

Five cell cultures of Huntington's-chorea fibroblasts exhibit greater than normal protein and lipid glycosylation when labelled with [U-14C]glucosamine. Oligosaccharide--polypeptide chains from all molecular-weight ranges are labelled differentially on sodium dodecyl sulphate/polyacrylamide-gel electrophoresis. This difference in protein glycosylation is not accompanied by any apparent difference in general cellular protein synthesis or by a differential rate of glucosamine uptake or decreased degradation of [14C]glycosylated macromolecules. Additionally [U-14C]glucosamine exclusively labels hexosamines and sialic acid of cellular macromolecules.

Full Text

Duke Authors

Cited Authors

  • Hung, WY; Mold, DE; Tourian, A

Published Date

  • September 15, 1980

Published In

Volume / Issue

  • 190 / 3

Start / End Page

  • 711 - 719

PubMed ID

  • 6451218

Pubmed Central ID

  • PMC1162151

International Standard Serial Number (ISSN)

  • 0264-6021

Digital Object Identifier (DOI)

  • 10.1042/bj1900711


  • eng

Conference Location

  • England