Huntington's-chorea fibroblasts. Cellular protein glycosylation.
Journal Article (Journal Article)
Five cell cultures of Huntington's-chorea fibroblasts exhibit greater than normal protein and lipid glycosylation when labelled with [U-14C]glucosamine. Oligosaccharide--polypeptide chains from all molecular-weight ranges are labelled differentially on sodium dodecyl sulphate/polyacrylamide-gel electrophoresis. This difference in protein glycosylation is not accompanied by any apparent difference in general cellular protein synthesis or by a differential rate of glucosamine uptake or decreased degradation of [14C]glycosylated macromolecules. Additionally [U-14C]glucosamine exclusively labels hexosamines and sialic acid of cellular macromolecules.
Full Text
Duke Authors
Cited Authors
- Hung, WY; Mold, DE; Tourian, A
Published Date
- September 15, 1980
Published In
Volume / Issue
- 190 / 3
Start / End Page
- 711 - 719
PubMed ID
- 6451218
Pubmed Central ID
- PMC1162151
International Standard Serial Number (ISSN)
- 0264-6021
Digital Object Identifier (DOI)
- 10.1042/bj1900711
Language
- eng
Conference Location
- England