L-glutamine D-fructose-6-P aminotransferase regulation by glucose-6-P and UDP-N-acetylglucosamine.

Journal Article (Journal Article)

L-Glutamine D-Fructose-6-P aminotransferase regulates hexosamine synthesis. An affinity purified human fibroblast aminotransferase and specific radioisotope assays developed by us were used to show an independent inhibition of the aminotransferase by Glucose-6-P. More interestingly, at concentration of UDP-N-Acetylglucosamine and glucose-6-P where either sugar has no independent inhibitory effect, there is an allosteric and significant inhibition of the aminotransferase.

Full Text

Duke Authors

Cited Authors

  • Tourian, A; Callahan, M; Hung, W

Published Date

  • December 1, 1983

Published In

Volume / Issue

  • 8 / 12

Start / End Page

  • 1589 - 1595

PubMed ID

  • 6687002

International Standard Serial Number (ISSN)

  • 0364-3190

Digital Object Identifier (DOI)

  • 10.1007/BF00964160

Language

  • eng

Conference Location

  • United States