L-glutamine D-fructose-6-P aminotransferase regulation by glucose-6-P and UDP-N-acetylglucosamine.
Journal Article (Journal Article)
L-Glutamine D-Fructose-6-P aminotransferase regulates hexosamine synthesis. An affinity purified human fibroblast aminotransferase and specific radioisotope assays developed by us were used to show an independent inhibition of the aminotransferase by Glucose-6-P. More interestingly, at concentration of UDP-N-Acetylglucosamine and glucose-6-P where either sugar has no independent inhibitory effect, there is an allosteric and significant inhibition of the aminotransferase.
Full Text
Duke Authors
Cited Authors
- Tourian, A; Callahan, M; Hung, W
Published Date
- December 1, 1983
Published In
Volume / Issue
- 8 / 12
Start / End Page
- 1589 - 1595
PubMed ID
- 6687002
International Standard Serial Number (ISSN)
- 0364-3190
Digital Object Identifier (DOI)
- 10.1007/BF00964160
Language
- eng
Conference Location
- United States