Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits.

Published

Journal Article

We used functional magnetic resonance imaging (fMRI) to investigate dysfunction in the amygdala and orbitofrontal cortex in adolescents with disruptive behavior disorders and psychopathic traits during a moral judgment task. Fourteen adolescents with psychopathic traits and 14 healthy controls were assessed using fMRI while they categorized illegal and legal behaviors in a moral judgment implicit association task. fMRI data were then analyzed using random-effects analysis of variance and functional connectivity. Youths with psychopathic traits showed reduced amygdala activity when making judgments about legal actions and reduced functional connectivity between the amygdala and orbitofrontal cortex during task performance. These results suggest that psychopathic traits are associated with amygdala and orbitofrontal cortex dysfunction. This dysfunction may relate to previous findings of disrupted moral judgment in this population.

Full Text

Duke Authors

Cited Authors

  • Marsh, AA; Finger, EC; Fowler, KA; Jurkowitz, ITN; Schechter, JC; Yu, HH; Pine, DS; Blair, RJR

Published Date

  • December 30, 2011

Published In

Volume / Issue

  • 194 / 3

Start / End Page

  • 279 - 286

PubMed ID

  • 22047730

Pubmed Central ID

  • 22047730

International Standard Serial Number (ISSN)

  • 0165-1781

Digital Object Identifier (DOI)

  • 10.1016/j.pscychresns.2011.07.008

Language

  • eng

Conference Location

  • Ireland