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Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits.

Publication ,  Journal Article
Marsh, AA; Finger, EC; Fowler, KA; Jurkowitz, ITN; Schechter, JC; Yu, HH; Pine, DS; Blair, RJR
Published in: Psychiatry Res
December 30, 2011

We used functional magnetic resonance imaging (fMRI) to investigate dysfunction in the amygdala and orbitofrontal cortex in adolescents with disruptive behavior disorders and psychopathic traits during a moral judgment task. Fourteen adolescents with psychopathic traits and 14 healthy controls were assessed using fMRI while they categorized illegal and legal behaviors in a moral judgment implicit association task. fMRI data were then analyzed using random-effects analysis of variance and functional connectivity. Youths with psychopathic traits showed reduced amygdala activity when making judgments about legal actions and reduced functional connectivity between the amygdala and orbitofrontal cortex during task performance. These results suggest that psychopathic traits are associated with amygdala and orbitofrontal cortex dysfunction. This dysfunction may relate to previous findings of disrupted moral judgment in this population.

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Published In

Psychiatry Res

DOI

ISSN

0165-1781

Publication Date

December 30, 2011

Volume

194

Issue

3

Start / End Page

279 / 286

Location

Ireland

Related Subject Headings

  • Psychiatry
  • Psychiatric Status Rating Scales
  • Prefrontal Cortex
  • Personality Inventory
  • Oxygen
  • Neural Pathways
  • Morals
  • Male
  • Magnetic Resonance Imaging
  • Judgment
 

Citation

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Marsh, A. A., Finger, E. C., Fowler, K. A., Jurkowitz, I. T. N., Schechter, J. C., Yu, H. H., … Blair, R. J. R. (2011). Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits. Psychiatry Res, 194(3), 279–286. https://doi.org/10.1016/j.pscychresns.2011.07.008
Marsh, Abigail A., Elizabeth C. Finger, Katherine A. Fowler, Ilana T. N. Jurkowitz, Julia C. Schechter, Henry H. Yu, Daniel S. Pine, and R. J. R. Blair. “Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits.Psychiatry Res 194, no. 3 (December 30, 2011): 279–86. https://doi.org/10.1016/j.pscychresns.2011.07.008.
Marsh AA, Finger EC, Fowler KA, Jurkowitz ITN, Schechter JC, Yu HH, et al. Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits. Psychiatry Res. 2011 Dec 30;194(3):279–86.
Marsh, Abigail A., et al. “Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits.Psychiatry Res, vol. 194, no. 3, Dec. 2011, pp. 279–86. Pubmed, doi:10.1016/j.pscychresns.2011.07.008.
Marsh AA, Finger EC, Fowler KA, Jurkowitz ITN, Schechter JC, Yu HH, Pine DS, Blair RJR. Reduced amygdala-orbitofrontal connectivity during moral judgments in youths with disruptive behavior disorders and psychopathic traits. Psychiatry Res. 2011 Dec 30;194(3):279–286.
Journal cover image

Published In

Psychiatry Res

DOI

ISSN

0165-1781

Publication Date

December 30, 2011

Volume

194

Issue

3

Start / End Page

279 / 286

Location

Ireland

Related Subject Headings

  • Psychiatry
  • Psychiatric Status Rating Scales
  • Prefrontal Cortex
  • Personality Inventory
  • Oxygen
  • Neural Pathways
  • Morals
  • Male
  • Magnetic Resonance Imaging
  • Judgment