Impact of activated vitamin D on insulin resistance in nondiabetic chronic kidney disease patients.

Journal Article (Journal Article)

UNLABELLED: Although vitamin D deficiency has been associated with increased insulin resistance, a causal link has not been established. Interpreting the relationship has been confounded by a close correlation between vitamin D deficiency and obesity. The current clinical approach of assessing endogenous 25-hydroxyvitamin D (25(OH)D) concentrations in patients with chronic kidney disease (CKD), and independently administering activated vitamin D (AD), allows a unique opportunity to clarify cause and effect in the relationship of vitamin D, obesity and insulin resistance. METHODS: We assessed how 25(OH)D and body mass index (BMI) related to fasting insulin concentrations in 120 nondiabetic patients with CKD. In addition, we described how treatment with AD modified these relationships. RESULTS: In the full cohort, fasting insulin concentrations varied inversely with both 25(OH)D (r = -0·22, P = 0·02) and BMI (r = -0·36, P < 0·0001). The administration of AD altered these relationships. In individuals treated with AD, there was no association between 25(OH)D and fasting insulin, and the mean fasting insulin concentrations were significantly lower than in those not receiving AD (40·5 ± 22·0 vs 54·1 ± 30·9 pm, P = 0·01). In a multivariate analysis, both AD treatment and BMI were independent predictors of fasting insulin. Furthermore, obese patients treated with AD had insulin concentrations similar to nonobese patients (46·1 ± 24·9 vs 40·2 ± 21·5 pm), whereas untreated obese patients had markedly higher fasting insulin concentrations (74·4 ± 33·4 pm, P = 0·003). CONCLUSION: 25(OH)D deficiency is associated with insulin resistance in CKD. Replacement with pharmacologic doses of AD is associated with lower fasting insulin concentrations, especially in obese patients.

Full Text

Duke Authors

Cited Authors

  • Friedman, DJ; Bhatt, N; Hayman, NS; Nichols, BJ; Herman, M; Nikolaev, N; Danziger, J

Published Date

  • July 2012

Published In

Volume / Issue

  • 77 / 1

Start / End Page

  • 56 - 61

PubMed ID

  • 21913955

Pubmed Central ID

  • PMC3638771

Electronic International Standard Serial Number (EISSN)

  • 1365-2265

Digital Object Identifier (DOI)

  • 10.1111/j.1365-2265.2011.04229.x


  • eng

Conference Location

  • England