Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony.

Journal Article (Journal Article;Review)

Recent data underscore the importance of intertissue communication in the maintenance of normal glucose homeostasis. Important signals are conveyed by hormones, cytokines, and fuel substrates and are sensed through a variety of cellular mechanisms. The ability of tissues to sense and adapt to changes in metabolic status and fuel availability is altered in insulin-resistant states including type 2 diabetes. Here we review the roles of glucose and its metabolites as signaling molecules and the diverse physiologic mechanisms for glucose sensing.

Full Text

Duke Authors

Cited Authors

  • Herman, MA; Kahn, BB

Published Date

  • July 2006

Published In

Volume / Issue

  • 116 / 7

Start / End Page

  • 1767 - 1775

PubMed ID

  • 16823474

Pubmed Central ID

  • PMC1483149

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI29027

Language

  • eng

Conference Location

  • United States