Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony.

Published

Journal Article (Review)

Recent data underscore the importance of intertissue communication in the maintenance of normal glucose homeostasis. Important signals are conveyed by hormones, cytokines, and fuel substrates and are sensed through a variety of cellular mechanisms. The ability of tissues to sense and adapt to changes in metabolic status and fuel availability is altered in insulin-resistant states including type 2 diabetes. Here we review the roles of glucose and its metabolites as signaling molecules and the diverse physiologic mechanisms for glucose sensing.

Full Text

Duke Authors

Cited Authors

  • Herman, MA; Kahn, BB

Published Date

  • July 2006

Published In

Volume / Issue

  • 116 / 7

Start / End Page

  • 1767 - 1775

PubMed ID

  • 16823474

Pubmed Central ID

  • 16823474

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/JCI29027

Language

  • eng