Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony.
Journal Article (Journal Article;Review)
Recent data underscore the importance of intertissue communication in the maintenance of normal glucose homeostasis. Important signals are conveyed by hormones, cytokines, and fuel substrates and are sensed through a variety of cellular mechanisms. The ability of tissues to sense and adapt to changes in metabolic status and fuel availability is altered in insulin-resistant states including type 2 diabetes. Here we review the roles of glucose and its metabolites as signaling molecules and the diverse physiologic mechanisms for glucose sensing.
Full Text
Duke Authors
Cited Authors
- Herman, MA; Kahn, BB
Published Date
- July 2006
Published In
Volume / Issue
- 116 / 7
Start / End Page
- 1767 - 1775
PubMed ID
- 16823474
Pubmed Central ID
- PMC1483149
International Standard Serial Number (ISSN)
- 0021-9738
Digital Object Identifier (DOI)
- 10.1172/JCI29027
Language
- eng
Conference Location
- United States