The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis.


Journal Article (Review)

Epidemiological studies link fructose consumption with metabolic disease, an association attributable in part to fructose-mediated lipogenesis. The mechanisms governing fructose-induced lipogenesis and disease remain debated. Acutely, fructose increases de novo lipogenesis through the efficient and uninhibited action of ketohexokinase and aldolase B which yields substrates for fatty-acid synthesis. Chronic fructose consumption further enhances the capacity for hepatic fructose metabolism by activating several key transcription factors (i.e., SREBP1c and ChREBP) which augment the expression of lipogenic enzymes, increasing lipogenesis and further compounding hypertriglyceridemia and hepatic steatosis. Hepatic insulin resistance develops from diacylglycerol-PKCɛ-mediated impairment of insulin signaling and possibly additional mechanisms. Initiatives that decrease fructose consumption and therapies that block fructose-mediated lipogenesis will be necessary to avert future metabolic pandemics.

Full Text

Duke Authors

Cited Authors

  • Herman, MA; Samuel, VT

Published Date

  • October 2016

Published In

Volume / Issue

  • 27 / 10

Start / End Page

  • 719 - 730

PubMed ID

  • 27387598

Pubmed Central ID

  • 27387598

Electronic International Standard Serial Number (EISSN)

  • 1879-3061

Digital Object Identifier (DOI)

  • 10.1016/j.tem.2016.06.005


  • eng

Conference Location

  • United States