Is chronic kidney disease associated with diabetic retinopathy in Asian adults?

Published

Journal Article

BACKGROUND: Diabetic nephropathy (DN) is commonly associated with diabetic retinopathy (DR). Few studies have demonstrated that chronic kidney disease (CKD) is associated with DR. However, it is not clear if CKD in the absence of albuminuria is associated with DR. METHODS: We included 301 participants with diabetes (Chinese, Malay and Indian ethnicity aged ≥24 years who participated in the Singapore Prospective Study Program (2003-2007). Retinal photographs taken from both eyes were graded for DR using the modified Airlie House Classification. We examined the association of CKD defined by low estimated glomerular filtration rate (eGFR) (<60 mL/min per 1.73 m(2) , n = 54), and albuminuria (urinary albumin-to-creatinine ratio ≥30, n = 116) with any-DR (n = 99) in logistic regression models. We replicated this analysis in another independent population-based sample of Malay adults (n = 265) with similar methodology in Singapore. RESULTS: 41% of those with low-eGFR had normoalbuminuria. In separate models, while albuminuria was significantly associated with any-DR, low-eGFR was not significantly associated with any-DR. In a model combining both markers, compared to the referent group (normal-eGFR+normoalbuminuria), the odds ratio (OR) (95% confidence interval [CI]) of any-DR were: 2.33 (1.27-4.27) for normal-eGFR+albuminuria, 1.38 (0.49-3.91) for low-eGFR + normoalbuminuria, and 2.64 (1.05-6.63) for low-eGFR+albuminuria. Similar findings for any-DR were observed in the replication cohort of Malay persons (3.56 [1.49-8.54] for normal-eGFR+albuminuria, 1.69 (0.52-5.55) for low-eGFR+normoalbuminuria, 4.34 [1.68-11.24] for low-eGFR+albuminuria. CONCLUSION: We demonstrated that CKD is associated with DR only in the presence of albuminuria suggesting that CKD is more likely related to diabetes in the presence of albuminuria.

Full Text

Duke Authors

Cited Authors

  • Sabanayagam, C; Foo, VHX; Ikram, MK; Huang, H; Lim, SC; Lamoureux, EL; Tai, ES; Wong, TY

Published Date

  • November 2014

Published In

Volume / Issue

  • 6 / 6

Start / End Page

  • 556 - 563

PubMed ID

  • 24636277

Pubmed Central ID

  • 24636277

Electronic International Standard Serial Number (EISSN)

  • 1753-0407

Digital Object Identifier (DOI)

  • 10.1111/1753-0407.12148

Language

  • eng

Conference Location

  • Australia