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Reliability and determinants of retinal vessel oximetry measurements in healthy eyes.

Publication ,  Journal Article
Yip, W; Siantar, R; Perera, SA; Milastuti, N; Ho, KK; Tan, B; Wong, TY; Cheung, CY
Published in: Invest Ophthalmol Vis Sci
October 9, 2014

PURPOSE: To assess the reliability and determinants of retinal vessel oximetry measurements with the Oxymap T1 Retinal Oximeter in normal Asian eyes. METHODS: Subjects older than 40 years without a history of stroke and heart disease were recruited from a community-based clinic. Subjects underwent standardized systemic and ocular examinations. Normal eyes were defined as eyes without major eye diseases such as age-related macular degeneration, glaucoma, or retinopathy. Retinal vessel oximetry levels were measured by using the Oxymap T1 Retinal Oximeter. Intra- and intergrader reliability of retinal vessel oximetry measurements were assessed by using 50 images. Intravisit repeatability of retinal vessel oximetry measurements was assessed by using 20 paired images. Univariable linear regression was performed to examine the associations between retinal vessel oximetry measurements and systemic determinants. RESULTS: A total of 118 retinal oximetry images were included in the final analysis. Intra- (intraclass correlation coefficient [ICC] values: 0.89-0.99) and intergrader (ICC values: 0.77-0.94) reliability, and intravisit (ICC values: 0.85-0.96) repeatability were both high. In the linear regression analysis, older age was associated with reduced overall retinal venular oximetry levels (β: -2.61%; 95% confidence interval [CI]: -4.92 to -0.29) and reduced inferior-nasal retinal venular oximetry levels (β: -3.53%; 95% CI: -6.07 to -0.99). CONCLUSIONS: The Oxymap Retinal Oximeter allows reliable and repeatable retinal vessel oximetry measurements. Age is the main factor that influences retinal venular oximetry levels and should be taken into account when retinal oximetry measurements are interpreted.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

October 9, 2014

Volume

55

Issue

11

Start / End Page

7104 / 7110

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Retinal Vessels
  • Retina
  • Reproducibility of Results
  • Reference Values
  • Oxygen Consumption
  • Oximetry
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yip, W., Siantar, R., Perera, S. A., Milastuti, N., Ho, K. K., Tan, B., … Cheung, C. Y. (2014). Reliability and determinants of retinal vessel oximetry measurements in healthy eyes. Invest Ophthalmol Vis Sci, 55(11), 7104–7110. https://doi.org/10.1167/iovs.13-13854
Yip, WanFen, Rosalynn Siantar, Shamira A. Perera, Nia Milastuti, Kee Ka Ho, Bernard Tan, Tien Yin Wong, and Carol Y. Cheung. “Reliability and determinants of retinal vessel oximetry measurements in healthy eyes.Invest Ophthalmol Vis Sci 55, no. 11 (October 9, 2014): 7104–10. https://doi.org/10.1167/iovs.13-13854.
Yip W, Siantar R, Perera SA, Milastuti N, Ho KK, Tan B, et al. Reliability and determinants of retinal vessel oximetry measurements in healthy eyes. Invest Ophthalmol Vis Sci. 2014 Oct 9;55(11):7104–10.
Yip, WanFen, et al. “Reliability and determinants of retinal vessel oximetry measurements in healthy eyes.Invest Ophthalmol Vis Sci, vol. 55, no. 11, Oct. 2014, pp. 7104–10. Pubmed, doi:10.1167/iovs.13-13854.
Yip W, Siantar R, Perera SA, Milastuti N, Ho KK, Tan B, Wong TY, Cheung CY. Reliability and determinants of retinal vessel oximetry measurements in healthy eyes. Invest Ophthalmol Vis Sci. 2014 Oct 9;55(11):7104–7110.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

October 9, 2014

Volume

55

Issue

11

Start / End Page

7104 / 7110

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Retinal Vessels
  • Retina
  • Reproducibility of Results
  • Reference Values
  • Oxygen Consumption
  • Oximetry
  • Ophthalmology & Optometry
  • Middle Aged
  • Male