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Ethnic variation in early age-related macular degeneration lesions between white Australians and Singaporean Asians.

Publication ,  Journal Article
Joachim, N; Mitchell, P; Younan, C; Burlutsky, G; Cheng, C-Y; Cheung, CMG; Zheng, Y; Moffitt, M; Wong, TY; Wang, JJ
Published in: Invest Ophthalmol Vis Sci
June 26, 2014

PURPOSE: We compared early age-related macular degeneration (AMD) lesion characteristics between white Australians and Singaporean Asians. METHODS: Participants of the Blue Mountains Eye Study (BMES; whites, n = 3508) and the Singapore Epidemiology of Eye Disease Study (SEED; Malay, n = 3280, Indian, n = 3400, and Chinese, n = 3353) underwent examinations, including retinal photography. The AMD lesions were assessed following the Wisconsin AMD grading protocol by the same photographic grader. Prevalence and characteristics of early AMD lesions were compared between the BMES and the SEED. The associations between ethnicity and early AMD lesion types were analyzed using logistic regression models adjusting for age, sex, smoking status, lipids, and genetic polymorphisms associated with AMD. RESULTS: After age-standardization to the BMES population, the prevalence of distinct soft drusen was significantly higher in Singaporeans compared to Australians (23.9%, 95% confidence interval [CI] 22.9-25.0 vs. 6.2%, 95% CI 5.3-7.0), with an adjusted odds ratio (OR) of 4.6 (95% CI 3.4-6.0). In contrast, the prevalence of indistinct soft or reticular drusen was significantly lower in Singaporeans compared to Australians (6.5%, 95% CI 5.9-7.1 vs. 8.3%, 95% CI 7.4-9.3, with nonsignificant adjusted OR of 1.2, 95% CI 0.8-1.7). Soft drusen of any type were present frequently at the inner and outer macula (within a zone ≥500 to <3000 μm radius from the foveal center) among Singaporeans, while among Australians soft drusen were present more frequently at the central macula (<500 μm radius). CONCLUSIONS: Singaporean Asians had a milder spectrum of early AMD lesions and lesion characteristics (predominantly distinct soft drusen and noncentral location) compared to white Australians.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

June 26, 2014

Volume

55

Issue

7

Start / End Page

4421 / 4429

Location

United States

Related Subject Headings

  • White People
  • Surveys and Questionnaires
  • Singapore
  • Retinal Drusen
  • Proteins
  • Prevalence
  • Polymorphism, Single Nucleotide
  • Ophthalmology & Optometry
  • Odds Ratio
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Joachim, N., Mitchell, P., Younan, C., Burlutsky, G., Cheng, C.-Y., Cheung, C. M. G., … Wang, J. J. (2014). Ethnic variation in early age-related macular degeneration lesions between white Australians and Singaporean Asians. Invest Ophthalmol Vis Sci, 55(7), 4421–4429. https://doi.org/10.1167/iovs.14-14476
Joachim, Nichole, Paul Mitchell, Christine Younan, George Burlutsky, Ching-Yu Cheng, Chui Ming Gemmy Cheung, Yingfeng Zheng, Mireille Moffitt, Tien Yin Wong, and Jie Jin Wang. “Ethnic variation in early age-related macular degeneration lesions between white Australians and Singaporean Asians.Invest Ophthalmol Vis Sci 55, no. 7 (June 26, 2014): 4421–29. https://doi.org/10.1167/iovs.14-14476.
Joachim N, Mitchell P, Younan C, Burlutsky G, Cheng C-Y, Cheung CMG, et al. Ethnic variation in early age-related macular degeneration lesions between white Australians and Singaporean Asians. Invest Ophthalmol Vis Sci. 2014 Jun 26;55(7):4421–9.
Joachim, Nichole, et al. “Ethnic variation in early age-related macular degeneration lesions between white Australians and Singaporean Asians.Invest Ophthalmol Vis Sci, vol. 55, no. 7, June 2014, pp. 4421–29. Pubmed, doi:10.1167/iovs.14-14476.
Joachim N, Mitchell P, Younan C, Burlutsky G, Cheng C-Y, Cheung CMG, Zheng Y, Moffitt M, Wong TY, Wang JJ. Ethnic variation in early age-related macular degeneration lesions between white Australians and Singaporean Asians. Invest Ophthalmol Vis Sci. 2014 Jun 26;55(7):4421–4429.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

June 26, 2014

Volume

55

Issue

7

Start / End Page

4421 / 4429

Location

United States

Related Subject Headings

  • White People
  • Surveys and Questionnaires
  • Singapore
  • Retinal Drusen
  • Proteins
  • Prevalence
  • Polymorphism, Single Nucleotide
  • Ophthalmology & Optometry
  • Odds Ratio
  • Middle Aged