Level-set based automatic cup-to-disc ratio determination using retinal fundus images in ARGALI.
Published
Journal Article
Glaucoma is a leading cause of permanent blindness. However, disease progression can be limited if detected early. The optic cup-to-disc ratio (CDR) is one of the main clinical indicators of glaucoma, and is currently determined manually, limiting its potential in mass screening. In this paper, we propose an automatic CDR determination method using a variational level-set approach to segment the optic disc and cup from retinal fundus images. The method is a core component of ARGALI, a system for automated glaucoma risk assessment. Threshold analysis is used in preprocessing to estimate the initial contour. Due to the presence of retinal vasculature traversing the disc and cup boundaries which can cause inaccuracies in the detected contours, an ellipse-fitting post-processing step is also introduced. The method was tested on 104 images from the Singapore Malay Eye Study, and it was found the results produced a clinically acceptable variation of up to 0.2 CDR units from the manually graded samples, with potential use in mass screening.
Full Text
Duke Authors
Cited Authors
- Wong, DK; Liu, J; Lim, JH; Jia, X; Yin, F; Li, H; Wong, TY
Published Date
- 2008
Published In
Volume / Issue
- 2008 /
Start / End Page
- 2266 - 2269
PubMed ID
- 19163151
Pubmed Central ID
- 19163151
International Standard Serial Number (ISSN)
- 1557-170X
Digital Object Identifier (DOI)
- 10.1109/IEMBS.2008.4649648
Language
- eng
Conference Location
- United States