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Retinal vascular parameter variations in patients with human immunodeficiency virus.

Publication ,  Journal Article
Tan, PB; Hee, OK; Cheung, C; Yeo, TK; Agrawal, R; Ng, J; Lim, TH; Wong, TY; Teoh, SC
Published in: Invest Ophthalmol Vis Sci
December 5, 2013

PURPOSE: To compare the retinal vascular parameters in patients with human immunodeficiency virus (HIV) infection with normal controls, and to determine the relationship between retinal vascular parameters and HIV-related blood biomarkers (CD4(+) T-lymphocytes count, presence of HIV RNA). METHODS: Case-control study of eighty-five patients with HIV on follow-up at the Communicable Disease Center, Singapore, and 251 age-, sex-, and race-matched normal healthy controls (case: control matching ≈ 1:3) selected from the Singapore Epidemiology of Eye Disease program were included in this study. Standardized retinal photographs were taken from patients and controls. Trained technicians measured quantitative retinal vascular parameters (retinal vascular caliber, branching angle, tortuosity, and fractal dimension) with a semiautomated computer-based program following a standardized protocol. RESULTS: HIV-patients had more tortuous arterioles (0.77 × [10(4)] vs. 0.59 × [10(4)], P < 0.001) and venules (0.90 × [10(4)] vs. 0.74 × [10(4)], P < 0.001), compared with healthy normal subjects. Amongst the HIV-patients, increasing HIV viral loads were associated with decreased retinal arteriolar caliber (P trend = 0.009) and decreased arteriolar-venular ratio (P trend = 0.025). CONCLUSIONS: Our study showed that patients with HIV have significant variations in retinal vasculature. Retinal vascular imaging may offer further insight into the pathophysiology behind HIV-related vascular disease in future.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

December 5, 2013

Volume

54

Issue

13

Start / End Page

7962 / 7967

Location

United States

Related Subject Headings

  • Venules
  • Retrospective Studies
  • Retinal Vessels
  • RNA, Viral
  • Ophthalmology & Optometry
  • Middle Aged
  • Microcirculation
  • Male
  • Humans
  • HIV Infections
 

Citation

APA
Chicago
ICMJE
MLA
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Tan, P. B., Hee, O. K., Cheung, C., Yeo, T. K., Agrawal, R., Ng, J., … Teoh, S. C. (2013). Retinal vascular parameter variations in patients with human immunodeficiency virus. Invest Ophthalmol Vis Sci, 54(13), 7962–7967. https://doi.org/10.1167/iovs.13-13081
Tan, Petrina B., Owen K. Hee, Carol Cheung, Tun Kuan Yeo, Rupesh Agrawal, James Ng, Tock Han Lim, Tien Yin Wong, and Stephen C. Teoh. “Retinal vascular parameter variations in patients with human immunodeficiency virus.Invest Ophthalmol Vis Sci 54, no. 13 (December 5, 2013): 7962–67. https://doi.org/10.1167/iovs.13-13081.
Tan PB, Hee OK, Cheung C, Yeo TK, Agrawal R, Ng J, et al. Retinal vascular parameter variations in patients with human immunodeficiency virus. Invest Ophthalmol Vis Sci. 2013 Dec 5;54(13):7962–7.
Tan, Petrina B., et al. “Retinal vascular parameter variations in patients with human immunodeficiency virus.Invest Ophthalmol Vis Sci, vol. 54, no. 13, Dec. 2013, pp. 7962–67. Pubmed, doi:10.1167/iovs.13-13081.
Tan PB, Hee OK, Cheung C, Yeo TK, Agrawal R, Ng J, Lim TH, Wong TY, Teoh SC. Retinal vascular parameter variations in patients with human immunodeficiency virus. Invest Ophthalmol Vis Sci. 2013 Dec 5;54(13):7962–7967.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

December 5, 2013

Volume

54

Issue

13

Start / End Page

7962 / 7967

Location

United States

Related Subject Headings

  • Venules
  • Retrospective Studies
  • Retinal Vessels
  • RNA, Viral
  • Ophthalmology & Optometry
  • Middle Aged
  • Microcirculation
  • Male
  • Humans
  • HIV Infections