Ocular parameters of biological ageing in HIV-infected individuals in South Africa: relationship with chronological age and systemic biomarkers of ageing.

Journal Article (Journal Article)

HIV-infected individuals have an increased risk of age-related morbidity despite antiretroviral treatment (ART). Several anatomic and functional ophthalmological parameters are associated with increasing chronological age. These may, therefore, potentially serve as biomarkers of ageing. We investigated associations between ocular parameters (lens density, retinal vessel calibre, corneal endothelium and retinal nerve fibre layer thickness) and two 'cellular' biomarkers of ageing (leukocyte telomere length and CDKN2A expression) and with frailty in a cross-sectional study of 216 HIV-infected individuals. All ocular parameters, telomere length and frailty were associated with chronological age, whereas CDKN2A expression was not. Retinal venular calibre and lens density were associated with shorter telomere length (p-trend=0.04, and 0.08, respectively), whereas CDKN2A expression and frailty status were not associated with ocular parameters. Longitudinal studies are warranted to assess the integration of retinal vascular calibre and lens density with systemic markers to develop an overall index of biological ageing in HIV infection.

Full Text

Duke Authors

Cited Authors

  • Pathai, S; Shiels, PG; Weiss, HA; Gilbert, CE; Peto, T; Bekker, L-G; Wood, R; Wong, TY; Lawn, SD

Published Date

  • September 2013

Published In

Volume / Issue

  • 134 / 9

Start / End Page

  • 400 - 406

PubMed ID

  • 23994067

Pubmed Central ID

  • PMC3818088

Electronic International Standard Serial Number (EISSN)

  • 1872-6216

Digital Object Identifier (DOI)

  • 10.1016/j.mad.2013.08.002


  • eng

Conference Location

  • Ireland