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Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls.

Publication ,  Journal Article
Zheng, W; Zhang, B; Cai, Q; Sung, H; Michailidou, K; Shi, J; Choi, J-Y; Long, J; Dennis, J; Humphreys, MK; Wang, Q; Lu, W; Gao, Y-T; Li, C ...
Published in: Hum Mol Genet
June 15, 2013

In a consortium including 23 637 breast cancer patients and 25 579 controls of East Asian ancestry, we investigated 70 single-nucleotide polymorphisms (SNPs) in 67 independent breast cancer susceptibility loci recently identified by genome-wide association studies (GWASs) conducted primarily in European-ancestry populations. SNPs in 31 loci showed an association with breast cancer risk at P < 0.05 in a direction consistent with that reported previously. Twenty-one of them remained statistically significant after adjusting for multiple comparisons with the Bonferroni-corrected significance level of <0.0015. Eight of the 70 SNPs showed a significantly different association with breast cancer risk by estrogen receptor (ER) status at P < 0.05. With the exception of rs2046210 at 6q25.1, the seven other SNPs showed a stronger association with ER-positive than ER-negative cancer. This study replicated all five genetic risk variants initially identified in Asians and provided evidence for associations of breast cancer risk in the East Asian population with nearly half of the genetic risk variants initially reported in GWASs conducted in European descendants. Taken together, these common genetic risk variants explain ~10% of excess familial risk of breast cancer in Asian populations.

Duke Scholars

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Published In

Hum Mol Genet

DOI

EISSN

1460-2083

Publication Date

June 15, 2013

Volume

22

Issue

12

Start / End Page

2539 / 2550

Location

England

Related Subject Headings

  • Republic of Korea
  • Receptors, Estrogen
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Humans
  • Genome-Wide Association Study
  • Genetics & Heredity
  • Genetic Predisposition to Disease
  • Female
  • China
 

Citation

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Zheng, W., Zhang, B., Cai, Q., Sung, H., Michailidou, K., Shi, J., … Kang, D. (2013). Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls. Hum Mol Genet, 22(12), 2539–2550. https://doi.org/10.1093/hmg/ddt089
Zheng, Wei, Ben Zhang, Qiuyin Cai, Hyuna Sung, Kyriaki Michailidou, Jiajun Shi, Ji-Yeob Choi, et al. “Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls.Hum Mol Genet 22, no. 12 (June 15, 2013): 2539–50. https://doi.org/10.1093/hmg/ddt089.
Zheng W, Zhang B, Cai Q, Sung H, Michailidou K, Shi J, et al. Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls. Hum Mol Genet. 2013 Jun 15;22(12):2539–50.
Zheng, Wei, et al. “Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls.Hum Mol Genet, vol. 22, no. 12, June 2013, pp. 2539–50. Pubmed, doi:10.1093/hmg/ddt089.
Zheng W, Zhang B, Cai Q, Sung H, Michailidou K, Shi J, Choi J-Y, Long J, Dennis J, Humphreys MK, Wang Q, Lu W, Gao Y-T, Li C, Cai H, Park SK, Yoo K-Y, Noh D-Y, Han W, Dunning AM, Benitez J, Vincent D, Bacot F, Tessier D, Kim S-W, Lee MH, Lee JW, Lee J-Y, Xiang Y-B, Zheng Y, Wang W, Ji B-T, Matsuo K, Ito H, Iwata H, Tanaka H, Wu AH, Tseng C-C, Van Den Berg D, Stram DO, Teo SH, Yip CH, Kang IN, Wong TY, Shen C-Y, Yu J-C, Huang C-S, Hou M-F, Hartman M, Miao H, Lee SC, Putti TC, Muir K, Lophatananon A, Stewart-Brown S, Siriwanarangsan P, Sangrajrang S, Shen H, Chen K, Wu P-E, Ren Z, Haiman CA, Sueta A, Kim MK, Khoo US, Iwasaki M, Pharoah PDP, Wen W, Hall P, Shu X-O, Easton DF, Kang D. Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls. Hum Mol Genet. 2013 Jun 15;22(12):2539–2550.
Journal cover image

Published In

Hum Mol Genet

DOI

EISSN

1460-2083

Publication Date

June 15, 2013

Volume

22

Issue

12

Start / End Page

2539 / 2550

Location

England

Related Subject Headings

  • Republic of Korea
  • Receptors, Estrogen
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Humans
  • Genome-Wide Association Study
  • Genetics & Heredity
  • Genetic Predisposition to Disease
  • Female
  • China