Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls.

Journal Article (Journal Article)

In a consortium including 23 637 breast cancer patients and 25 579 controls of East Asian ancestry, we investigated 70 single-nucleotide polymorphisms (SNPs) in 67 independent breast cancer susceptibility loci recently identified by genome-wide association studies (GWASs) conducted primarily in European-ancestry populations. SNPs in 31 loci showed an association with breast cancer risk at P < 0.05 in a direction consistent with that reported previously. Twenty-one of them remained statistically significant after adjusting for multiple comparisons with the Bonferroni-corrected significance level of <0.0015. Eight of the 70 SNPs showed a significantly different association with breast cancer risk by estrogen receptor (ER) status at P < 0.05. With the exception of rs2046210 at 6q25.1, the seven other SNPs showed a stronger association with ER-positive than ER-negative cancer. This study replicated all five genetic risk variants initially identified in Asians and provided evidence for associations of breast cancer risk in the East Asian population with nearly half of the genetic risk variants initially reported in GWASs conducted in European descendants. Taken together, these common genetic risk variants explain ~10% of excess familial risk of breast cancer in Asian populations.

Full Text

Duke Authors

Cited Authors

  • Zheng, W; Zhang, B; Cai, Q; Sung, H; Michailidou, K; Shi, J; Choi, J-Y; Long, J; Dennis, J; Humphreys, MK; Wang, Q; Lu, W; Gao, Y-T; Li, C; Cai, H; Park, SK; Yoo, K-Y; Noh, D-Y; Han, W; Dunning, AM; Benitez, J; Vincent, D; Bacot, F; Tessier, D; Kim, S-W; Lee, MH; Lee, JW; Lee, J-Y; Xiang, Y-B; Zheng, Y; Wang, W; Ji, B-T; Matsuo, K; Ito, H; Iwata, H; Tanaka, H; Wu, AH; Tseng, C-C; Van Den Berg, D; Stram, DO; Teo, SH; Yip, CH; Kang, IN; Wong, TY; Shen, C-Y; Yu, J-C; Huang, C-S; Hou, M-F; Hartman, M; Miao, H; Lee, SC; Putti, TC; Muir, K; Lophatananon, A; Stewart-Brown, S; Siriwanarangsan, P; Sangrajrang, S; Shen, H; Chen, K; Wu, P-E; Ren, Z; Haiman, CA; Sueta, A; Kim, MK; Khoo, US; Iwasaki, M; Pharoah, PDP; Wen, W; Hall, P; Shu, X-O; Easton, DF; Kang, D

Published Date

  • June 15, 2013

Published In

Volume / Issue

  • 22 / 12

Start / End Page

  • 2539 - 2550

PubMed ID

  • 23535825

Pubmed Central ID

  • PMC3658167

Electronic International Standard Serial Number (EISSN)

  • 1460-2083

Digital Object Identifier (DOI)

  • 10.1093/hmg/ddt089

Language

  • eng

Conference Location

  • England