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Serum C-reactive protein level and prehypertension in two Asian populations.

Publication ,  Journal Article
Sabanayagam, C; Shankar, A; Lee, J; Wong, TY; Tai, ES
Published in: J Hum Hypertens
April 2013

Few previous studies in Western populations have reported an association between C-reactive protein (CRP) and prehypertension. However, no previous study has examined this association in Asians. We examined individuals who were free of hypertension from two independent population-based studies in Singapore: the Singapore Prospective Study Programme (SP2, n=2843 Chinese, Malay and Indians aged 24 years) and the Singapore Malay Eye Study (SiMES, n=957 Malays, aged 40-80 years). Prehypertension was defined as systolic blood pressure (BP) 120-139 mm Hg or diastolic BP 80-89 mm Hg. CRP was analyzed as categories (<1, 1-3, >3 mg l(-1)). The prevalence of prehypertension increased with increasing categories of CRP in both cohorts (P for trend <0.05 in both cohorts). After adjusting for potential confounders including body mass index (BMI), smoking and diabetes, persons with higher levels of CRP were more likely to have prehypertension in both SP2 (compared with CRP <1 mg l(-1), odds ratio (OR) 1.23, 95% confidence interval (CI) 1.03-1.48 for CRP 1-3 and OR 1.67, 95% CI 1.32-2.10 for >3 mg l(-1)) and SiMES (OR 1.45, 95% CI 1.04-2.01 and OR 1.56, 95% CI 1.07-2.27) respectively. In conclusion, data from two population-based Asian cohorts suggest that elevated serum CRP levels are associated with prehypertension.

Duke Scholars

Published In

J Hum Hypertens

DOI

EISSN

1476-5527

Publication Date

April 2013

Volume

27

Issue

4

Start / End Page

231 / 236

Location

England

Related Subject Headings

  • Up-Regulation
  • Singapore
  • Risk Factors
  • Risk Assessment
  • Prospective Studies
  • Prevalence
  • Prehypertension
  • Odds Ratio
  • Multivariate Analysis
  • Middle Aged
 

Citation

APA
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ICMJE
MLA
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Sabanayagam, C., Shankar, A., Lee, J., Wong, T. Y., & Tai, E. S. (2013). Serum C-reactive protein level and prehypertension in two Asian populations. J Hum Hypertens, 27(4), 231–236. https://doi.org/10.1038/jhh.2011.117
Sabanayagam, C., A. Shankar, J. Lee, T. Y. Wong, and E. S. Tai. “Serum C-reactive protein level and prehypertension in two Asian populations.J Hum Hypertens 27, no. 4 (April 2013): 231–36. https://doi.org/10.1038/jhh.2011.117.
Sabanayagam C, Shankar A, Lee J, Wong TY, Tai ES. Serum C-reactive protein level and prehypertension in two Asian populations. J Hum Hypertens. 2013 Apr;27(4):231–6.
Sabanayagam, C., et al. “Serum C-reactive protein level and prehypertension in two Asian populations.J Hum Hypertens, vol. 27, no. 4, Apr. 2013, pp. 231–36. Pubmed, doi:10.1038/jhh.2011.117.
Sabanayagam C, Shankar A, Lee J, Wong TY, Tai ES. Serum C-reactive protein level and prehypertension in two Asian populations. J Hum Hypertens. 2013 Apr;27(4):231–236.

Published In

J Hum Hypertens

DOI

EISSN

1476-5527

Publication Date

April 2013

Volume

27

Issue

4

Start / End Page

231 / 236

Location

England

Related Subject Headings

  • Up-Regulation
  • Singapore
  • Risk Factors
  • Risk Assessment
  • Prospective Studies
  • Prevalence
  • Prehypertension
  • Odds Ratio
  • Multivariate Analysis
  • Middle Aged