Retinal vascular geometry and glaucoma: the Singapore Malay Eye Study.


Journal Article

PURPOSE: To determine the associations of geometric measurements (tortuosity, branching angle, and fractal dimension) of retinal vessels with glaucoma. DESIGN: Population-based, cross-sectional study. PARTICIPANTS: Persons aged 40 to 80 years who participated in the Singapore Malay Eye Study (n=3280; 78.7% response rate). METHODS: Quantitative retinal vascular parameters (tortuosity, branching angle, and fractal dimension) were measured from digital retinal fundus photographs using a computer-assisted program following a standardized grading protocol. Glaucoma was diagnosed according to the International Society of Geographic and Epidemiological Ophthalmology classification system. MAIN OUTCOME MEASURES: The associations among retinal vascular parameters with glaucoma, the main glaucoma subtype primary open-angle glaucoma (POAG), and ocular hypertension (OHT). RESULTS: A total of 123 persons (4.4% of the 2789 participants) had glaucoma in the final analysis, 87 (70.7%) of whom were diagnosed with POAG. After adjusting for age, sex, body mass index, diabetes, hypertension, smoking, axial length, and intraocular pressure (IOP), decreased retinal arteriolar tortuosity (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.38-2.18, comparing lowest vs. highest quartiles), decreased retinal venular tortuosity (OR, 1.59; 95% CI, 1.29-1.97), and narrower retinal venular branching angle (OR, 1.22; 95% CI, 1.00-1.48) were associated with glaucoma. Similar associations were found between these retinal vascular parameters and POAG. Decreased retinal vascular fractal dimension was associated with OHT (OR 1.37; 95% CI, 1.04-1.82). CONCLUSIONS: Certain features of retinal vascular geometry are associated with glaucomatous optic neuropathy independently of vascular risk factors and IOP. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Full Text

Duke Authors

Cited Authors

  • Wu, R; Cheung, CY-L; Saw, SM; Mitchell, P; Aung, T; Wong, TY

Published Date

  • January 2013

Published In

Volume / Issue

  • 120 / 1

Start / End Page

  • 77 - 83

PubMed ID

  • 23009894

Pubmed Central ID

  • 23009894

Electronic International Standard Serial Number (EISSN)

  • 1549-4713

Digital Object Identifier (DOI)

  • 10.1016/j.ophtha.2012.07.063


  • eng

Conference Location

  • United States