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Microvascular dilatation after haemodialysis is determined by the volume of fluid removed and fall in mean arterial pressure.

Publication ,  Journal Article
Tow, FKN-FH; Ooi, QL; Wong, TY; Kawasaki, R; Colville, D; Mount, P; Savige, J
Published in: Kidney Blood Press Res
2012

BACKGROUND/AIMS: The effects of haemodialysis on the microcirculation are poorly understood. This study examined the changes in small vessel calibre. METHODS: 24 patients (including 12 males, median age 62.5 years, range 30-87) underwent digital retinal photography immediately before and after routine haemodialysis. Arteriolar and venular calibres were measured from the images by a trained grader using a highly reproducible, computer-assisted method. RESULTS: Patients had an average 2.0 ± 0.3 litres of fluid removed with dialysis, and their mean arterial blood pressure fell by 6.8 mm Hg (CI 13.8-0.2, p = 0.06). Retinal arteriole calibre did not change (mean difference 2.3 µm, CI -1.1 to 5.7, p = 0.17) but the venules dilated (mean difference 12.7 µm, CI 7.3-18.3, p < 0.001). Calibre returned to baseline by 2 h. Venules dilated less in diabetics than non-diabetics (mean difference -6.2 µm, CI -9.6 to -2.9, p < 0.01). Retinal venular dilatation correlated positively with the volume of fluid removed per kilogramme body weight (5.9, CI 0.2-11.5, p = 0.04), and negatively with the fall in mean arterial pressure (-0.36, CI -0.72 to -0.01, p < 0.05) after adjusting for age, gender, diabetes and dyslipidaemia. CONCLUSION: Haemodialysis is associated with systemic venular dilatation.

Duke Scholars

Published In

Kidney Blood Press Res

DOI

EISSN

1423-0143

Publication Date

2012

Volume

35

Issue

6

Start / End Page

644 / 648

Location

Switzerland

Related Subject Headings

  • Vasodilation
  • Urology & Nephrology
  • Retinal Vessels
  • Renal Dialysis
  • Middle Aged
  • Microcirculation
  • Male
  • Humans
  • Female
  • Blood Volume
 

Citation

APA
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ICMJE
MLA
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Tow, F.-F., Ooi, Q. L., Wong, T. Y., Kawasaki, R., Colville, D., Mount, P., & Savige, J. (2012). Microvascular dilatation after haemodialysis is determined by the volume of fluid removed and fall in mean arterial pressure. Kidney Blood Press Res, 35(6), 644–648. https://doi.org/10.1159/000341732
Tow, Foong Kien Newk-Fon Hey, Qi Lun Ooi, Tien Y. Wong, Ryo Kawasaki, Deb Colville, Peter Mount, and Judy Savige. “Microvascular dilatation after haemodialysis is determined by the volume of fluid removed and fall in mean arterial pressure.Kidney Blood Press Res 35, no. 6 (2012): 644–48. https://doi.org/10.1159/000341732.
Tow FKN-FH, Ooi QL, Wong TY, Kawasaki R, Colville D, Mount P, et al. Microvascular dilatation after haemodialysis is determined by the volume of fluid removed and fall in mean arterial pressure. Kidney Blood Press Res. 2012;35(6):644–8.
Tow, Foong Kien Newk-Fon Hey, et al. “Microvascular dilatation after haemodialysis is determined by the volume of fluid removed and fall in mean arterial pressure.Kidney Blood Press Res, vol. 35, no. 6, 2012, pp. 644–48. Pubmed, doi:10.1159/000341732.
Tow FKN-FH, Ooi QL, Wong TY, Kawasaki R, Colville D, Mount P, Savige J. Microvascular dilatation after haemodialysis is determined by the volume of fluid removed and fall in mean arterial pressure. Kidney Blood Press Res. 2012;35(6):644–648.
Journal cover image

Published In

Kidney Blood Press Res

DOI

EISSN

1423-0143

Publication Date

2012

Volume

35

Issue

6

Start / End Page

644 / 648

Location

Switzerland

Related Subject Headings

  • Vasodilation
  • Urology & Nephrology
  • Retinal Vessels
  • Renal Dialysis
  • Middle Aged
  • Microcirculation
  • Male
  • Humans
  • Female
  • Blood Volume