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Novel versus traditional risk markers for diabetic retinopathy.

Publication ,  Journal Article
Sasongko, MB; Wong, TY; Nguyen, TT; Shaw, JE; Jenkins, AJ; Wang, JJ
Published in: Diabetologia
March 2012

AIMS/HYPOTHESIS: To explore the relative contribution of novel and traditional risk markers for diabetic retinopathy (DR). METHODS: A clinic-based study of 224 diabetic patients (85 type 1, 139 type 2) from a diabetes clinic was performed. DR was graded from fundus photographs according to the Airlie House Classification system and classified as absent or present (at least ETDRS level 14). Novel risk markers assessed included serum apolipoprotein (Apo) AI and B, skin microvascular responses to acetylcholine (endothelium-dependent) and sodium nitroprusside (endothelium-independent) iontophoresis, flicker-light-induced retinal vasodilation and retinal vascular tortuosity. Relative contribution was determined by semi-partial correlation coefficient generated from a logistic regression model containing all traditional and novel risk markers simultaneously. RESULTS: There were 144 (64.3%) participants with DR. Of the novel markers, ApoAI, flicker-light-induced vasodilation and retinal arteriolar tortuosity were significantly associated with DR, independently of traditional measures (all p < 0.03). Diabetes duration contributed most (51%) to the risk of DR, followed by ApoAI (16%), systolic blood pressure (13%), retinal arteriolar tortuosity (8%) and flicker-light-induced venular and arteriolar dilation (3% and 0.5%, respectively). CONCLUSIONS/INTERPRETATION: ApoAI and retinal arteriolar tortuosity made considerable contributions to DR risk, independently of traditional risk markers. Findings from this study suggest that serum ApoAI and retinal arteriolar tortuosity may be novel and independent risk markers of DR.

Duke Scholars

Published In

Diabetologia

DOI

EISSN

1432-0428

Publication Date

March 2012

Volume

55

Issue

3

Start / End Page

666 / 670

Location

Germany

Related Subject Headings

  • Young Adult
  • Vasodilation
  • Severity of Illness Index
  • Sensitivity and Specificity
  • Risk Factors
  • Retinal Vessels
  • Middle Aged
  • Male
  • Light
  • Humans
 

Citation

APA
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ICMJE
MLA
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Sasongko, M. B., Wong, T. Y., Nguyen, T. T., Shaw, J. E., Jenkins, A. J., & Wang, J. J. (2012). Novel versus traditional risk markers for diabetic retinopathy. Diabetologia, 55(3), 666–670. https://doi.org/10.1007/s00125-011-2424-x
Sasongko, M. B., T. Y. Wong, T. T. Nguyen, J. E. Shaw, A. J. Jenkins, and J. J. Wang. “Novel versus traditional risk markers for diabetic retinopathy.Diabetologia 55, no. 3 (March 2012): 666–70. https://doi.org/10.1007/s00125-011-2424-x.
Sasongko MB, Wong TY, Nguyen TT, Shaw JE, Jenkins AJ, Wang JJ. Novel versus traditional risk markers for diabetic retinopathy. Diabetologia. 2012 Mar;55(3):666–70.
Sasongko, M. B., et al. “Novel versus traditional risk markers for diabetic retinopathy.Diabetologia, vol. 55, no. 3, Mar. 2012, pp. 666–70. Pubmed, doi:10.1007/s00125-011-2424-x.
Sasongko MB, Wong TY, Nguyen TT, Shaw JE, Jenkins AJ, Wang JJ. Novel versus traditional risk markers for diabetic retinopathy. Diabetologia. 2012 Mar;55(3):666–670.
Journal cover image

Published In

Diabetologia

DOI

EISSN

1432-0428

Publication Date

March 2012

Volume

55

Issue

3

Start / End Page

666 / 670

Location

Germany

Related Subject Headings

  • Young Adult
  • Vasodilation
  • Severity of Illness Index
  • Sensitivity and Specificity
  • Risk Factors
  • Retinal Vessels
  • Middle Aged
  • Male
  • Light
  • Humans