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Arterial compliance and retinal vascular caliber in cerebrovascular disease.

Publication ,  Journal Article
Cheung, N; Islam, FMA; Jacobs, DR; Sharrett, AR; Klein, R; Polak, JF; Cotch, MF; Klein, BE; Ouyang, P; Wong, TY
Published in: Ann Neurol
December 2007

OBJECTIVE: Arterial stiffness is a newly recognized risk factor for stroke. Whether this is mediated by small- or large-artery disease is unknown. In this study, we examined the relationship between arterial stiffness and retinal vascular caliber. METHODS: A cross-sectional, population-based study of 5,731 participants (aged 45-84 years) who were free of clinical cardiovascular disease (the Multi-Ethnic Study of Atherosclerosis). Retinal arteriolar and venular calibers were measured from retinal photographs according to standardized protocols. Small- and large-artery compliance was determined from pulse contour analysis. RESULTS: After adjusting for age, sex, blood pressure, diabetes, smoking, lipid profile, and other risk factors, reduced large-artery compliance was associated with smaller retinal arteriolar caliber; each standard deviation decrease in large-artery compliance was associated with a 0.70 microm (p = 0.002) decrease in retinal arteriolar caliber. After adjusting for the same set of risk factors, reduced small-artery compliance was associated with wider retinal venular caliber; each standard deviation decrease in small artery compliance was associated with a 1.43 microm (p = 0.001) increase in retinal venular caliber. These associations remained significant after further adjustments for large-vessel atherosclerosis (carotid intima-media thickness, coronary artery calcium, and ankle-arm index). INTERPRETATION: Reduced arterial wall compliance in large arterial beds is associated with retinal arteriolar narrowing, whereas reduced arterial wall compliance in small arterial beds is associated with retinal venular widening. These data may provide further insights into the effects of altered arterial stiffness on the cerebral microcirculation.

Duke Scholars

Published In

Ann Neurol

DOI

EISSN

1531-8249

Publication Date

December 2007

Volume

62

Issue

6

Start / End Page

618 / 624

Location

United States

Related Subject Headings

  • Venules
  • Vasomotor System
  • Retinal Vessels
  • Radial Artery
  • Prospective Studies
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Intracranial Arteriosclerosis
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cheung, N., Islam, F. M. A., Jacobs, D. R., Sharrett, A. R., Klein, R., Polak, J. F., … Wong, T. Y. (2007). Arterial compliance and retinal vascular caliber in cerebrovascular disease. Ann Neurol, 62(6), 618–624. https://doi.org/10.1002/ana.21236
Cheung, Ning, FM Amirul Islam, David R. Jacobs, A Richey Sharrett, Ronald Klein, Joseph F. Polak, Mary F. Cotch, Barbara E. Klein, Pamala Ouyang, and Tien Y. Wong. “Arterial compliance and retinal vascular caliber in cerebrovascular disease.Ann Neurol 62, no. 6 (December 2007): 618–24. https://doi.org/10.1002/ana.21236.
Cheung N, Islam FMA, Jacobs DR, Sharrett AR, Klein R, Polak JF, et al. Arterial compliance and retinal vascular caliber in cerebrovascular disease. Ann Neurol. 2007 Dec;62(6):618–24.
Cheung, Ning, et al. “Arterial compliance and retinal vascular caliber in cerebrovascular disease.Ann Neurol, vol. 62, no. 6, Dec. 2007, pp. 618–24. Pubmed, doi:10.1002/ana.21236.
Cheung N, Islam FMA, Jacobs DR, Sharrett AR, Klein R, Polak JF, Cotch MF, Klein BE, Ouyang P, Wong TY. Arterial compliance and retinal vascular caliber in cerebrovascular disease. Ann Neurol. 2007 Dec;62(6):618–624.
Journal cover image

Published In

Ann Neurol

DOI

EISSN

1531-8249

Publication Date

December 2007

Volume

62

Issue

6

Start / End Page

618 / 624

Location

United States

Related Subject Headings

  • Venules
  • Vasomotor System
  • Retinal Vessels
  • Radial Artery
  • Prospective Studies
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Intracranial Arteriosclerosis
  • Humans