Myopia, axial length, and OCT characteristics of the macula in Singaporean children.

Journal Article (Journal Article)

PURPOSE: The purpose of this study was to evaluate the associations between macular volume and thickness, as assessed by optic coherence tomography (OCT), with refraction and axial length (AL) in children. METHODS: A total of 104 Chinese school children (51 girls and 53 boys) 11 to 12 years of age were randomly selected from one school during the 2005 examination in the Singapore Cohort Study of the Risk Factors for Myopia (SCORM). Cycloplegic autorefraction was performed to obtain refraction (defined as spherical equivalent [SE]) and ultrasound biometry performed to obtain the AL. Macular volume and thickness were then measured (StratusOCT3; Carl Zeiss Meditec, Dublin, CA). RESULTS: Children with moderate myopia (SE at least -3.0 D) tended to have smaller total macular volume and thinner quadrant-specific macular thickness (except in the inferior and superior inner quadrants), followed by children with low myopia (-0.5-0.5 D). Total macular volume was positively associated with SE (beta=1.58, 95% CI, 0.84 to 2.32, standardized beta=0.14, P<0.001) and negatively associated with AL (beta=-1.20, 95% CI, -1.62 to -0.79, standardized beta=0.45, P<0.001) in multiple linear regression models controlling for age and gender. CONCLUSIONS: In children, increasing axial myopia was associated with reduced macular volume and thickness. These findings suggest that early anatomic changes may be present in the retinas of children with axial myopia.

Full Text

Duke Authors

Cited Authors

  • Luo, H-D; Gazzard, G; Fong, A; Aung, T; Hoh, ST; Loon, S-C; Healey, P; Tan, DTH; Wong, T-Y; Saw, S-M

Published Date

  • July 2006

Published In

Volume / Issue

  • 47 / 7

Start / End Page

  • 2773 - 2781

PubMed ID

  • 16799013

International Standard Serial Number (ISSN)

  • 0146-0404

Digital Object Identifier (DOI)

  • 10.1167/iovs.05-1380


  • eng

Conference Location

  • United States