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Retinal vascular caliber and brachial flow-mediated dilation: the Multi-Ethnic Study of Atherosclerosis.

Publication ,  Journal Article
Nguyen, TT; Islam, FMA; Farouque, HMO; Klein, R; Klein, BEK; Cotch, MF; Herrington, DM; Wong, TY
Published in: Stroke
July 2010

BACKGROUND AND PURPOSE: Retinal vascular caliber changes have been shown to predict stroke, but the underlying mechanism of this association is unknown. We examined the relationship between retinal vascular caliber with brachial flow-mediated dilation (FMD), a measure of systemic endothelial function. METHODS: The Multi-Ethnic Study of Atherosclerosis (MESA) is a population-based study of persons 45 to 84 years of age residing in 6 US communities free of clinical cardiovascular disease at baseline. Brachial FMD data were collected at baseline (July 2000 to June 2002), and retinal vascular caliber was measured from digital retinal photographs at the second examination, immediately after the first (August 2002 to January 2004). Data were available for 2851 participants for analysis. RESULTS: The mean brachial FMD was 4.39+/-2.79%. After adjusting for age and gender, brachial FMD was reduced in persons with wider retinal venular caliber (changes in FMD -0.25, 95% CI, -0.36, - 0.13; P<0.001, per SD increase in venular caliber). This relationship persists after adjusting for systolic blood pressure, serum total cholesterol, use of lipid-lowering and antihypertensive medication, body mass index, current smoking status, and hemoglobinA(1C) (-0.18; 95% CI -0.30, - 0.06; P=0.004, per SD increase in venular caliber). Brachial FMD was not associated with retinal arteriolar caliber. CONCLUSIONS: Persons with wider retinal venules have reduced brachial FMD, independent of other vascular risk factors. This suggests that retinal venular caliber, previously shown to predict stroke, may be a marker of underlying systemic endothelial dysfunction.

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Published In

Stroke

DOI

EISSN

1524-4628

Publication Date

July 2010

Volume

41

Issue

7

Start / End Page

1343 / 1348

Location

United States

Related Subject Headings

  • Vasodilation
  • Vascular Capacitance
  • Retinal Vessels
  • Regional Blood Flow
  • Prospective Studies
  • Population Surveillance
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Nguyen, T. T., Islam, F. M. A., Farouque, H. M. O., Klein, R., Klein, B. E. K., Cotch, M. F., … Wong, T. Y. (2010). Retinal vascular caliber and brachial flow-mediated dilation: the Multi-Ethnic Study of Atherosclerosis. Stroke, 41(7), 1343–1348. https://doi.org/10.1161/STROKEAHA.110.581017
Nguyen, Thanh T., FM Amirul Islam, HM Omar Farouque, Ronald Klein, Barbara E. K. Klein, Mary Frances Cotch, David M. Herrington, and Tien Yin Wong. “Retinal vascular caliber and brachial flow-mediated dilation: the Multi-Ethnic Study of Atherosclerosis.Stroke 41, no. 7 (July 2010): 1343–48. https://doi.org/10.1161/STROKEAHA.110.581017.
Nguyen TT, Islam FMA, Farouque HMO, Klein R, Klein BEK, Cotch MF, et al. Retinal vascular caliber and brachial flow-mediated dilation: the Multi-Ethnic Study of Atherosclerosis. Stroke. 2010 Jul;41(7):1343–8.
Nguyen, Thanh T., et al. “Retinal vascular caliber and brachial flow-mediated dilation: the Multi-Ethnic Study of Atherosclerosis.Stroke, vol. 41, no. 7, July 2010, pp. 1343–48. Pubmed, doi:10.1161/STROKEAHA.110.581017.
Nguyen TT, Islam FMA, Farouque HMO, Klein R, Klein BEK, Cotch MF, Herrington DM, Wong TY. Retinal vascular caliber and brachial flow-mediated dilation: the Multi-Ethnic Study of Atherosclerosis. Stroke. 2010 Jul;41(7):1343–1348.

Published In

Stroke

DOI

EISSN

1524-4628

Publication Date

July 2010

Volume

41

Issue

7

Start / End Page

1343 / 1348

Location

United States

Related Subject Headings

  • Vasodilation
  • Vascular Capacitance
  • Retinal Vessels
  • Regional Blood Flow
  • Prospective Studies
  • Population Surveillance
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans