The retinal vasculature as a fractal: methodology, reliability, and relationship to blood pressure.

Journal Article

OBJECTIVE: Fractals represent a type of derived geometric pattern that permits the characterization of the branching pattern of retinal vessels. We examined a new semiautomated method to measure retinal vessel fractals. DESIGN: Methodology study. PARTICIPANTS: Three hundred randomly selected participants from the population-based Blue Mountains Eye Study. METHODS: We developed a semiautomated computer program to measure the fractal dimension (D(f)) of the retinal vessels from digitized images of disk-centered retinal photographs. Two trained graders masked to participant characteristics measured D(f) of right eye images of participants. Reliability was determined by repeat grading of the images from 60 participants, and association with systolic and diastolic blood pressure was examined in all 300 participants. MAIN OUTCOME MEASURE: D(f) of the retinal vessels. RESULTS: Mean D(f) was 1.437 with a standard deviation of 0.025. Intragrader and intergrader reliability estimates were high with intraclass correlation ranging from 0.93 to 0.95. D(f) was inversely correlated with age (r = -0.42, P = 0.001) and systolic blood pressure (r = -0.29, P<0.0001). After adjustment for age and sex, mean D(f) was significantly lower in participants with than without hypertension (D(f) difference 0.01, P = 0.02). CONCLUSIONS: The D(f) of the retinal vessels can be reliably measured from photographs and shows a strong inverse correlation with blood pressure. These data suggest that the D(f) may be a measure of early microvascular alterations from elevated blood pressure. Further studies to examine the systemic and ocular correlates of the D(f) of the retinal vessels are needed.

Full Text

Duke Authors

Cited Authors

  • Liew, G; Wang, JJ; Cheung, N; Zhang, YP; Hsu, W; Lee, ML; Mitchell, P; Tikellis, G; Taylor, B; Wong, TY

Published Date

  • November 2008

Published In

Volume / Issue

  • 115 / 11

Start / End Page

  • 1951 - 1956

PubMed ID

  • 18692247

Electronic International Standard Serial Number (EISSN)

  • 1549-4713

International Standard Serial Number (ISSN)

  • 0161-6420

Digital Object Identifier (DOI)

  • 10.1016/j.ophtha.2008.05.029

Language

  • eng