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Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations.

Publication ,  Journal Article
Dorajoo, R; Blakemore, AIF; Sim, X; Ong, RT-H; Ng, DPK; Seielstad, M; Wong, T-Y; Saw, S-M; Froguel, P; Liu, J; Tai, E-S
Published in: Int J Obes (Lond)
January 2012

OBJECTIVE: Recent genome-wide association studies (GWAS) have identified 38 obesity-associated loci among European populations. However, their contribution to obesity in other ethnicities is largely unknown. METHODS: We utilised five GWAS (N=10 482) from Chinese (three cohorts, including one with type 2 diabetes and another one of children), Malay and Indian ethnic groups from Singapore. Data sets were analysed individually and subsequently in combined meta-analysis for Z-score body-mass index (BMI) associations. RESULTS: Variants at the FTO locus showed the strongest associations with BMI Z-score after meta-analysis (P-values 1.16 × 10(-7)-7.95 × 10(-7)). We further detected associations with nine other index obesity variants close to the MC4R, GNPDA2, TMEM18, QPCTL/GIPR, BDNF, ETV5, MAP2K5/SKOR1, SEC16B and TNKS/MSRA loci (meta-analysis P-values ranging from 3.58 × 10(-4)-1.44 × 10(-2)). Three other single-nucleotide polymorphisms (SNPs) from CADM2, PTBP2 and FAIM2 were associated with BMI (P-value ≤ 0.0418) in at least one dataset. The neurotrophin/TRK pathway (P-value=0.029) was highlighted by pathway-based analysis of loci that had statistically significant associations among Singaporean populations. CONCLUSION: Our data confirm the role of FTO in obesity predisposition among Chinese, Malays and Indians, the three major Asian ethnic groups. We additionally detected associations for 12 obesity-associated SNPs among Singaporeans. Thus, it is likely that Europeans and Asians share some of the genetic predisposition to obesity. Furthermore, the neurotrophin/TRK signalling may have a central role for common obesity among Asians.

Duke Scholars

Published In

Int J Obes (Lond)

DOI

EISSN

1476-5497

Publication Date

January 2012

Volume

36

Issue

1

Start / End Page

159 / 163

Location

England

Related Subject Headings

  • White People
  • Singapore
  • Signal Transduction
  • Receptor, trkA
  • Proteins
  • Polymorphism, Single Nucleotide
  • Obesity
  • Nerve Growth Factors
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dorajoo, R., Blakemore, A. I. F., Sim, X., Ong, R.-H., Ng, D. P. K., Seielstad, M., … Tai, E.-S. (2012). Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations. Int J Obes (Lond), 36(1), 159–163. https://doi.org/10.1038/ijo.2011.86
Dorajoo, R., A. I. F. Blakemore, X. Sim, R. T. -. H. Ong, D. P. K. Ng, M. Seielstad, T. -. Y. Wong, et al. “Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations.Int J Obes (Lond) 36, no. 1 (January 2012): 159–63. https://doi.org/10.1038/ijo.2011.86.
Dorajoo R, Blakemore AIF, Sim X, Ong RT-H, Ng DPK, Seielstad M, et al. Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations. Int J Obes (Lond). 2012 Jan;36(1):159–63.
Dorajoo, R., et al. “Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations.Int J Obes (Lond), vol. 36, no. 1, Jan. 2012, pp. 159–63. Pubmed, doi:10.1038/ijo.2011.86.
Dorajoo R, Blakemore AIF, Sim X, Ong RT-H, Ng DPK, Seielstad M, Wong T-Y, Saw S-M, Froguel P, Liu J, Tai E-S. Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations. Int J Obes (Lond). 2012 Jan;36(1):159–163.

Published In

Int J Obes (Lond)

DOI

EISSN

1476-5497

Publication Date

January 2012

Volume

36

Issue

1

Start / End Page

159 / 163

Location

England

Related Subject Headings

  • White People
  • Singapore
  • Signal Transduction
  • Receptor, trkA
  • Proteins
  • Polymorphism, Single Nucleotide
  • Obesity
  • Nerve Growth Factors
  • Middle Aged
  • Male