Homocysteine and retinal vein occlusion: a population-based study.

Journal Article (Journal Article)

PURPOSE: To report population data on the association between homocysteinemia and retinal vein occlusion (RVO). DESIGN: Cross-sectional, population-based study. METHODS: Total serum homocysteine (tHcy) was estimated in subjects attending the second Blue Mountains Eye Study (BMES) (n = 3509, aged >49 years). Its association with RVO (graded from retinal photographs) was examined. RESULTS: Homocysteine was more strongly associated with RVO in younger than older participants. In those aged <70 years, homocysteine levels >15 micromol/l were associated with increased odds of RVO, odds ratio (OR) 3.76; 95% confidence interval (CI) 1.06-13.40, in multivariable-adjusted analyses. Each 1 micromol/l increase in homocysteine was associated with a 7% increased odds of RVO, OR 1.07; CI 0.99-1.17 (P = .08). CONCLUSION: This population-based study showed that elevated serum homocysteine is associated with the presence of RVO, independent of other risk factors.

Full Text

Duke Authors

Cited Authors

  • Chua, B; Kifley, A; Wong, TY; Mitchell, P

Published Date

  • January 2005

Published In

Volume / Issue

  • 139 / 1

Start / End Page

  • 181 - 182

PubMed ID

  • 15652845

International Standard Serial Number (ISSN)

  • 0002-9394

Digital Object Identifier (DOI)

  • 10.1016/j.ajo.2004.06.084


  • eng

Conference Location

  • United States