Homocysteine and retinal vein occlusion: a population-based study.
PURPOSE: To report population data on the association between homocysteinemia and retinal vein occlusion (RVO). DESIGN: Cross-sectional, population-based study. METHODS: Total serum homocysteine (tHcy) was estimated in subjects attending the second Blue Mountains Eye Study (BMES) (n = 3509, aged >49 years). Its association with RVO (graded from retinal photographs) was examined. RESULTS: Homocysteine was more strongly associated with RVO in younger than older participants. In those aged <70 years, homocysteine levels >15 micromol/l were associated with increased odds of RVO, odds ratio (OR) 3.76; 95% confidence interval (CI) 1.06-13.40, in multivariable-adjusted analyses. Each 1 micromol/l increase in homocysteine was associated with a 7% increased odds of RVO, OR 1.07; CI 0.99-1.17 (P = .08). CONCLUSION: This population-based study showed that elevated serum homocysteine is associated with the presence of RVO, independent of other risk factors.
Duke Scholars
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Related Subject Headings
- Risk Factors
- Retinal Vein Occlusion
- Ophthalmology & Optometry
- Odds Ratio
- Middle Aged
- Male
- Hyperhomocysteinemia
- Humans
- Homocysteine
- Female
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Risk Factors
- Retinal Vein Occlusion
- Ophthalmology & Optometry
- Odds Ratio
- Middle Aged
- Male
- Hyperhomocysteinemia
- Humans
- Homocysteine
- Female