Familial aggregation of age-related macular degeneration in the Utah population.

Journal Article

We examined familial aggregation and risk of age-related macular degeneration in the Utah population using a population-based case-control study. Over one million unique patient records were searched within the University of Utah Health Sciences Center and the Utah Population Database (UPDB), identifying 4764 patients with AMD. Specialized kinship analysis software was used to test for familial aggregation of disease, estimate the magnitude of familial risks, and identify families at high risk for disease. The population-attributable risk (PAR) for AMD was calculated to be 0.34. Recurrence risks in relatives indicate increased relative risks in siblings (2.95), first cousins (1.29), second cousins (1.13), and parents (5.66) of affected cases. There were 16 extended large families with AMD identified for potential use in genetic studies. Each family had five or more living affected members. The familial aggregation of AMD shown in this study exemplifies the merit of the UPDB and supports recent research demonstrating significant genetic contribution to disease development and progression.

Full Text

Duke Authors

Cited Authors

  • Luo, L; Harmon, J; Yang, X; Chen, H; Patel, S; Mineau, G; Yang, Z; Constantine, R; Buehler, J; Kaminoh, Y; Ma, X; Wong, TY; Zhang, M; Zhang, K

Published Date

  • February 2008

Published In

Volume / Issue

  • 48 / 3

Start / End Page

  • 494 - 500

PubMed ID

  • 18252239

Electronic International Standard Serial Number (EISSN)

  • 1878-5646

International Standard Serial Number (ISSN)

  • 0042-6989

Digital Object Identifier (DOI)

  • 10.1016/j.visres.2007.11.013

Language

  • eng