Do retinopathy signs in non-diabetic individuals predict the subsequent risk of diabetes?


Journal Article

Isolated retinopathy signs are common in non-diabetic individuals and have been shown to be associated with impaired glucose metabolism. In a cohort of people without diabetes, the association of these retinopathy signs and subsequent development of diabetes were examined.A population based cohort study of 7992 people aged 49-73 years without diabetes was conducted. Retinal photographs of these participants were evaluated for the presence of retinopathy signs according to a standardised protocol. Incident cases of diabetes were identified prospectively.After a follow up of 3 years, 291 (3.6%) people developed incident diabetes. In the total cohort, retinopathy was not significantly associated with incident diabetes (4.7% v 3.6%, multivariable adjusted odds ratio (OR) 1.1, 95% confidence intervals (CI), 0.7 to 1.9). However, among participants with a positive family history of diabetes, retinopathy was associated with incident diabetes (10.4% v 4.8%, multivariable adjusted OR 2.3, 95% CI, 1.0 to 5.3). Among participants without a family history of diabetes, retinopathy was not associated with incident diabetesIn individuals with a family history of diabetes, retinopathy signs predict subsequent risk of clinical diabetes.

Full Text

Cited Authors

  • Wong, TY; Mohamed, Q; Klein, R; Couper, DJ

Published Date

  • March 2006

Published In

Volume / Issue

  • 90 / 3

Start / End Page

  • 301 - 303

PubMed ID

  • 16488949

Pubmed Central ID

  • 16488949

Electronic International Standard Serial Number (EISSN)

  • 1468-2079

International Standard Serial Number (ISSN)

  • 0007-1161

Digital Object Identifier (DOI)

  • 10.1136/bjo.2005.084400


  • eng