Relationship between retinal structures and retinal vessel caliber in normal adolescents.

Journal Article (Journal Article;Multicenter Study)

PURPOSE: To describe the normal physiological relationship between retinal arteriolar and venular caliber and retinal nerve fiber layer (RNFL), macular, and optic nerve head parameters. METHODS: The Sydney Childhood Eye Study assessed 2038 adolescents aged 12 years. Retinal vessel calibers were measured from digital fundus photographs using standardized protocols. Optical coherence tomography measurements of RNFL, macular, and optic nerve head parameters were obtained with the Fast-scan protocol of the Stratus OCT (Carl Zeiss Meditec, Inc., Dublin, CA). Mixed model analyses were performed. RESULTS: After adjustment for covariates, each micrometer increase in RNFL thickness was associated with a 0.22-microm (0.15%, P < 0.0001) and 0.49-microm (0.23%, P < 0.0001) increase in mean arteriolar and venular caliber, respectively. This positive association existed across all RNFL quadrants (0.07%-0.24%, P

Full Text

Duke Authors

Cited Authors

  • Samarawickrama, C; Huynh, SC; Wang, JJ; Pai, A; Joachim, N; Burlutsky, G; Wong, TY; Mitchell, P

Published Date

  • December 2009

Published In

Volume / Issue

  • 50 / 12

Start / End Page

  • 5619 - 5624

PubMed ID

  • 19661230

Electronic International Standard Serial Number (EISSN)

  • 1552-5783

Digital Object Identifier (DOI)

  • 10.1167/iovs.09-3878


  • eng

Conference Location

  • United States