Retinal arteriolar wall signs and early age-related macular degeneration: the singapore malay eye study.


Journal Article

PURPOSE: To determine whether retinal arteriolar wall signs are associated with early age-related macular degeneration (AMD). DESIGN: Population-based cross-sectional study. METHODS: The Singapore Malay Eye Study (SiMES) is a population-based eye survey including 3,280 (78.7% response) persons aged 40 to 80 years. Retinal arteriolar wall signs and AMD were assessed from photographs by trained technicians, according to standardized protocols. Data on major cardiovascular risk factors and blood pressure were collected. RESULTS: Of the 3,280 participants, 2,541 had photographs that were gradable for both AMD and retinal arteriolar wall signs. Early AMD was present in 76 subjects. There were no significant associations of any retinal arteriolar wall signs with early AMD. For specific AMD signs, retinal arteriolar wall opacification was associated with presence of soft distinct drusen (odds ratio [OR] 1.58, 95% confidence interval [CI]: 1.06, 2.35). This association was most significant among non-statin users (OR 1.90, 95% CI: 1.23, 2.93). Focal arteriolar narrowing was associated with retinal hypopigmentation (OR 1.67, 95% CI: 1.02, 2.73). Arteriovenous nicking was not associated with soft drusen (OR 0.89, 95% CI: 0.51, 1.57), hyperpigmentation (OR 0.49, 95% CI: 0.22, 1.08), or hypopigmentation (OR 0.86, 95% CI: 0.46, 1.61). CONCLUSIONS: Retinal arteriolar wall signs are not consistently associated with early AMD. We report a new association of retinal arteriolar wall opacification and the presence of soft drusen. This finding could support the hypothesis of a link between lipids and drusen formation.

Full Text

Duke Authors

Cited Authors

  • Cheung, CMG; Cheung, CY-L; Yang, EL; Mitchell, P; Wang, JJ; Wong, TY

Published Date

  • July 2011

Published In

Volume / Issue

  • 152 / 1

Start / End Page

  • 108 - 113.e1

PubMed ID

  • 21570050

Pubmed Central ID

  • 21570050

Electronic International Standard Serial Number (EISSN)

  • 1879-1891

Digital Object Identifier (DOI)

  • 10.1016/j.ajo.2011.01.012


  • eng

Conference Location

  • United States