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Reproducibility of the retinal vascular response to flicker light in Asians.

Publication ,  Journal Article
Nguyen, TT; Kreis, AJ; Kawasaki, R; Wang, JJ; Seifert, B-U; Vilser, W; Nagel, E; Wong, TY
Published in: Curr Eye Res
December 2009

PURPOSE: Dilation of retinal vessels in response to diffuse luminance flicker may reflect endothelial function. Although this has previously been shown to be reproducible in whites, there have been no similar data in Asians. We assess the reproducibility of repeated measurements of this response in Asians. MATERIAL AND METHODS: Healthy Asians (n = 33) with normal vision and no history of glaucoma, age-related macular degeneration, cataract, or retinal arterial/venous occlusion participated in this study. Repeated measures from the same subjects were taken 30-60 min apart using the Dynamic Vessel Analyser (DVA, IMEDOS, Jena, Germany). Modification was made to the shape of the light source for Asian participants. Correlations of the first and second measures were assessed using Pearson correlation (R(2)), and agreement between the two measures was shown using Bland-Altman plots. RESULTS: After modification to the shape of the light source, almost perfect correlation was found between the 1st and 2nd measurements of baseline arteriolar (R(2) = 0.95) and venular diameters (R(2) = 0.98) of arteriolar maximum dilation (R(2) = 0.85). Substantially high correlation between the 1st and 2nd measurements of venular maximum dilation was found (R(2) = 0.80). CONCLUSIONS: Measurements of the dilation response of retinal vessels to diffuse luminance flicker an Asian sample using the DVA show high reproducibility for repeated measures over a short period of time. Such measurements may allow non-invasive quantification of endothelial function to study its association with systemic and ocular diseases.

Duke Scholars

Published In

Curr Eye Res

DOI

EISSN

1460-2202

Publication Date

December 2009

Volume

34

Issue

12

Start / End Page

1082 / 1088

Location

England

Related Subject Headings

  • Young Adult
  • Vasodilation
  • Time Factors
  • Software
  • Retinal Vessels
  • Reproducibility of Results
  • Reference Values
  • Photic Stimulation
  • Ophthalmology & Optometry
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nguyen, T. T., Kreis, A. J., Kawasaki, R., Wang, J. J., Seifert, B.-U., Vilser, W., … Wong, T. Y. (2009). Reproducibility of the retinal vascular response to flicker light in Asians. Curr Eye Res, 34(12), 1082–1088. https://doi.org/10.3109/02713680903353764
Nguyen, Thanh T., Andreas J. Kreis, Ryo Kawasaki, Jie Jin Wang, Bernd-U Seifert, Walthard Vilser, Edgar Nagel, and Tien Y. Wong. “Reproducibility of the retinal vascular response to flicker light in Asians.Curr Eye Res 34, no. 12 (December 2009): 1082–88. https://doi.org/10.3109/02713680903353764.
Nguyen TT, Kreis AJ, Kawasaki R, Wang JJ, Seifert B-U, Vilser W, et al. Reproducibility of the retinal vascular response to flicker light in Asians. Curr Eye Res. 2009 Dec;34(12):1082–8.
Nguyen, Thanh T., et al. “Reproducibility of the retinal vascular response to flicker light in Asians.Curr Eye Res, vol. 34, no. 12, Dec. 2009, pp. 1082–88. Pubmed, doi:10.3109/02713680903353764.
Nguyen TT, Kreis AJ, Kawasaki R, Wang JJ, Seifert B-U, Vilser W, Nagel E, Wong TY. Reproducibility of the retinal vascular response to flicker light in Asians. Curr Eye Res. 2009 Dec;34(12):1082–1088.

Published In

Curr Eye Res

DOI

EISSN

1460-2202

Publication Date

December 2009

Volume

34

Issue

12

Start / End Page

1082 / 1088

Location

England

Related Subject Headings

  • Young Adult
  • Vasodilation
  • Time Factors
  • Software
  • Retinal Vessels
  • Reproducibility of Results
  • Reference Values
  • Photic Stimulation
  • Ophthalmology & Optometry
  • Middle Aged