Evidence of early retinal microvascular changes in patients with type 2 diabetes and depression.

Journal Article (Journal Article)

OBJECTIVE: To examine retinal vascular caliber, an indicator of early microvascular disease and depression in patients with Type 2 diabetes. METHODS: We conducted a clinic-based study, comparing participants with Type 2 diabetes with major depression (n = 43), without depression (n = 49), and healthy controls without diabetes or depression (n = 54). Retinal vascular caliber was measured from digital photographs. Depression status was determined, using standardized clinical assessment. RESULTS: After adjusting for age and gender, participants with diabetes and depression had larger arteriolar and venular calibers (147.7 microm for arteriolar and 215.7 microm for venular calibers) than participants with diabetes but without depression (143.3 microm and 213.9 microm) and healthy controls (135.8 microm and 202.5 microm, p for trend = .002 for arteriolar and p = .02 for venular caliber). In multivariate models adjusting for duration of diabetes, systolic blood pressure, cigarette smoking, serum glucose, Cerebrovascular Risk Factor Scale, Cumulative Illness Rating Scale, and retinopathy levels, this relationship remained significant for retinal arterioles (p = .02) but not for retinal venules (p = .10). CONCLUSIONS: These data show that patients with Type 2 diabetes with major depression have wider retinal arterioles, supporting the concept that depression is associated with early microvascular changes in Type 2 diabetes.

Full Text

Duke Authors

Cited Authors

  • Nguyen, TT; Wong, TY; Islam, FMA; Hubbard, L; Ajilore, O; Haroon, E; Darwin, C; Esser, B; Kumar, A

Published Date

  • July 2010

Published In

Volume / Issue

  • 72 / 6

Start / End Page

  • 535 - 538

PubMed ID

  • 20368470

Electronic International Standard Serial Number (EISSN)

  • 1534-7796

Digital Object Identifier (DOI)

  • 10.1097/PSY.0b013e3181da90f4


  • eng

Conference Location

  • United States