Apolipoprotein E gene polymorphisms and retinal vascular signs: the atherosclerosis risk in communities (ARIC) study.


Journal Article

OBJECTIVE: To examine the association between apolipoprotein E (APOE) gene polymorphisms and retinal microvascular signs. METHODS: Population-based, cross-sectional study. Participants from the Atherosclerosis Risk in Communities Study (n=10,036; aged 49-73 years) had retinal photographs taken in 1 randomly selected eye. Photographs were graded for presence of retinal microvascular signs using a standardized protocol; a computer-assisted method was used to measure retinal vessel diameter. DNA from blood samples was analyzed for common APOE alleles. RESULTS: After adjusting for age, sex, systolic blood pressure, total serum cholesterol, triglycerides, and other covariates, APOE epsilon 4 was associated with nondiabetic retinopathy in white (multivariate-adjusted odds ratio, 1.3; 95% confidence interval, 1.0-1.6) and black (multivariate-adjusted odds ratio, 1.4; 95% confidence interval, 1.0-2.1) individuals. Other retinal microvascular signs were not strongly associated with APOE polymorphisms. Neither retinal arteriolar nor venular diameter was associated with APOE polymorphisms in white or black individuals. CONCLUSIONS: Apolipoprotein E epsilon 4 was weakly associated with retinopathy in persons without diabetes. Other signs were less consistently associated with APOE polymorphisms.

Full Text

Duke Authors

Cited Authors

  • Liew, G; Shankar, A; Wang, JJ; Klein, R; Bray, MS; Couper, DJ; Sharrett, AR; Wong, TY

Published Date

  • June 2007

Published In

Volume / Issue

  • 125 / 6

Start / End Page

  • 813 - 818

PubMed ID

  • 17562993

Pubmed Central ID

  • 17562993

International Standard Serial Number (ISSN)

  • 0003-9950

Digital Object Identifier (DOI)

  • 10.1001/archopht.125.6.813


  • eng

Conference Location

  • United States