C-reactive protein, gamma-glutamyltransferase and type 2 diabetes in a Chinese population.

Journal Article

BACKGROUND: We studied the association of C-reactive protein (CRP), gamma-glutamyltransferase (GGT) and type 2 diabetes in Chinese. METHOD: A population-based cross-sectional study. RESULTS: CRP and GGT levels were significantly higher in participants with diabetes than in those without (P<0.001). Higher CRP levels were positively associated with prevalent type 2 diabetes after adjustment for age, sex, smoking, alcohol consumption, physical activity, family history of diabetes, body mass index, waist circumference, waist/hip ratio, education, systolic blood pressure, triglycerides, high density lipoprotein cholesterol, use of antihypertensive drugs, aspirin and lipid-lowering agents, with multivariable odds ratios (OR) of 1.55 (95% confidence interval (CI), 1.05-2.27, P trend=0.005, comparing quartile 4 to quartile 1). However, after further adjustment for GGT, the association was completely attenuated (fourth quartile OR 1.23, 95% CI, 0.83-1.82, P trend=0.127). Moreover, the association of CRP and prevalent type 2 diabetes was stronger in subjects with GGT values above the median than in those with GGT values below the median. Increasing serum GGT quartiles were positively associated with prevalent type 2 diabetes after adjustment for potential confounding variables (P for trend <0.001). CONCLUSION: CRP may not be an independent risk factor for type 2 diabetes, at least in Chinese people.

Full Text

Duke Authors

Cited Authors

  • Wen, J; Liang, Y; Wang, F; Sun, L; Guo, Y; Duan, X; Liu, X; Wong, TY; Lu, X; Wang, N

Published Date

  • February 2010

Published In

Volume / Issue

  • 411 / 3-4

Start / End Page

  • 198 - 203

PubMed ID

  • 19900432

Electronic International Standard Serial Number (EISSN)

  • 1873-3492

International Standard Serial Number (ISSN)

  • 0009-8981

Digital Object Identifier (DOI)

  • 10.1016/j.cca.2009.11.002

Language

  • eng